Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ

A. Miyawaki, F. Matsushita, Y. Ryo, K. Mikoshiba

研究成果: Article

67 引用 (Scopus)

抄録

We report the molecular cloning and characterization of two secretory proteins specifically expressed in vomeronasal and posterior glands of the nasal septum, the ducts of which open into the lumen of the vomeronasal organ. These two proteins are members of the lipocalin superfamily, consisting of hydrophobic ligand carriers. We immunohistochemically localized one of the proteins in the mucus covering the vomeronasal sensory epithelium, where the primary reception of pheromone takes place. The immunoreactivity on the vomeronasal sensory epithelium was evident in the neonatal and post-pubertal periods, when the close contact between animals plays critical roles in suckling and sexual behaviors, respectively. These results suggest that small lipophilic molecules stimulate the accessory olfactory system to regulate the reproductive behavior of mice.

元の言語English
ページ(範囲)5835-5842
ページ数8
ジャーナルEMBO Journal
13
発行部数24
出版物ステータスPublished - 01-12-1994
外部発表Yes

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Vomeronasal Organ
Lipocalins
Pheromones
Epithelium
Nasal Septum
Reproductive Behavior
Proteins
Cloning
Accessories
Molecular Cloning
Mucus
Sexual Behavior
Ducts
Animals
Ligands
Molecules

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Miyawaki, A. ; Matsushita, F. ; Ryo, Y. ; Mikoshiba, K. / Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ. :: EMBO Journal. 1994 ; 巻 13, 番号 24. pp. 5835-5842.
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Miyawaki, A, Matsushita, F, Ryo, Y & Mikoshiba, K 1994, 'Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ', EMBO Journal, 巻. 13, 番号 24, pp. 5835-5842.

Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ. / Miyawaki, A.; Matsushita, F.; Ryo, Y.; Mikoshiba, K.

:: EMBO Journal, 巻 13, 番号 24, 01.12.1994, p. 5835-5842.

研究成果: Article

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