Possible protective effect of serum β-carotene levels on the association between interleukin-1B C-31T polymorphism and hypertension in a Japanese population

Atsumi Yanagisawa, Koji Suzuki, Asami Kimura, Yoshinori Ito, Nobuyuki Hamajima, Takashi Inoue

研究成果: Article

6 引用 (Scopus)

抄録

Background & aims: Recent studies have indicated a close relationship between hypertension and inflammation. Antioxidant substances, including β-carotene, are known to be preventive factors for hypertension. We investigated the effect of serum β-carotene levels on the association between the interleukin-1beta (IL-1B) C-31T polymorphism and hypertension. Methods: Subjects were 625 inhabitants (200 males and 425 females) of Japan, aged 39-70 years, who attended a health check-up examination in 2003. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting two-pair primers. Serum β-carotene levels were measured using high-performance liquid chromatography. Results: The TT genotype of IL-1B C-31T was associated with an increased risk of hypertension in all subjects (Odds Ratio [OR] = 1.82, 95% Confidence Interval [95% CI] = 1.09-3.06, compared with CC genotype). Among male CC carriers, those with high serum β-carotene levels had a significantly lower OR (OR = 0.25, 95% CI = 0.06-0.95) for hypertension relative to those with low serum β-carotene levels. The TT carriers had a significantly higher OR compared with the CC carriers among males with high serum β-carotene levels (OR = 5.03, 95% CI = 1.34-21.58) and among females with low serum β-carotene levels (OR = 2.47, 95% CI = 1.04-6.00). Conclusion: This study suggests that the IL-1B C-31T polymorphism is associated with hypertension, and that this association is modulated by serum β-carotene levels.

元の言語English
ページ(範囲)198-202
ページ数5
ジャーナルClinical Nutrition
28
発行部数2
DOI
出版物ステータスPublished - 01-04-2009

Fingerprint

Interleukins
Carotenoids
Hypertension
Odds Ratio
Serum
Interleukin-1beta
Population
Confidence Intervals
Genotype
Japan
Antioxidants
High Pressure Liquid Chromatography
Inflammation
Polymerase Chain Reaction
Health

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

これを引用

Yanagisawa, Atsumi ; Suzuki, Koji ; Kimura, Asami ; Ito, Yoshinori ; Hamajima, Nobuyuki ; Inoue, Takashi. / Possible protective effect of serum β-carotene levels on the association between interleukin-1B C-31T polymorphism and hypertension in a Japanese population. :: Clinical Nutrition. 2009 ; 巻 28, 番号 2. pp. 198-202.
@article{c7d688de3f934b388f77b9289555a818,
title = "Possible protective effect of serum β-carotene levels on the association between interleukin-1B C-31T polymorphism and hypertension in a Japanese population",
abstract = "Background & aims: Recent studies have indicated a close relationship between hypertension and inflammation. Antioxidant substances, including β-carotene, are known to be preventive factors for hypertension. We investigated the effect of serum β-carotene levels on the association between the interleukin-1beta (IL-1B) C-31T polymorphism and hypertension. Methods: Subjects were 625 inhabitants (200 males and 425 females) of Japan, aged 39-70 years, who attended a health check-up examination in 2003. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting two-pair primers. Serum β-carotene levels were measured using high-performance liquid chromatography. Results: The TT genotype of IL-1B C-31T was associated with an increased risk of hypertension in all subjects (Odds Ratio [OR] = 1.82, 95{\%} Confidence Interval [95{\%} CI] = 1.09-3.06, compared with CC genotype). Among male CC carriers, those with high serum β-carotene levels had a significantly lower OR (OR = 0.25, 95{\%} CI = 0.06-0.95) for hypertension relative to those with low serum β-carotene levels. The TT carriers had a significantly higher OR compared with the CC carriers among males with high serum β-carotene levels (OR = 5.03, 95{\%} CI = 1.34-21.58) and among females with low serum β-carotene levels (OR = 2.47, 95{\%} CI = 1.04-6.00). Conclusion: This study suggests that the IL-1B C-31T polymorphism is associated with hypertension, and that this association is modulated by serum β-carotene levels.",
author = "Atsumi Yanagisawa and Koji Suzuki and Asami Kimura and Yoshinori Ito and Nobuyuki Hamajima and Takashi Inoue",
year = "2009",
month = "4",
day = "1",
doi = "10.1016/j.clnu.2009.01.020",
language = "English",
volume = "28",
pages = "198--202",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",
number = "2",

}

Possible protective effect of serum β-carotene levels on the association between interleukin-1B C-31T polymorphism and hypertension in a Japanese population. / Yanagisawa, Atsumi; Suzuki, Koji; Kimura, Asami; Ito, Yoshinori; Hamajima, Nobuyuki; Inoue, Takashi.

:: Clinical Nutrition, 巻 28, 番号 2, 01.04.2009, p. 198-202.

研究成果: Article

TY - JOUR

T1 - Possible protective effect of serum β-carotene levels on the association between interleukin-1B C-31T polymorphism and hypertension in a Japanese population

AU - Yanagisawa, Atsumi

AU - Suzuki, Koji

AU - Kimura, Asami

AU - Ito, Yoshinori

AU - Hamajima, Nobuyuki

AU - Inoue, Takashi

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Background & aims: Recent studies have indicated a close relationship between hypertension and inflammation. Antioxidant substances, including β-carotene, are known to be preventive factors for hypertension. We investigated the effect of serum β-carotene levels on the association between the interleukin-1beta (IL-1B) C-31T polymorphism and hypertension. Methods: Subjects were 625 inhabitants (200 males and 425 females) of Japan, aged 39-70 years, who attended a health check-up examination in 2003. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting two-pair primers. Serum β-carotene levels were measured using high-performance liquid chromatography. Results: The TT genotype of IL-1B C-31T was associated with an increased risk of hypertension in all subjects (Odds Ratio [OR] = 1.82, 95% Confidence Interval [95% CI] = 1.09-3.06, compared with CC genotype). Among male CC carriers, those with high serum β-carotene levels had a significantly lower OR (OR = 0.25, 95% CI = 0.06-0.95) for hypertension relative to those with low serum β-carotene levels. The TT carriers had a significantly higher OR compared with the CC carriers among males with high serum β-carotene levels (OR = 5.03, 95% CI = 1.34-21.58) and among females with low serum β-carotene levels (OR = 2.47, 95% CI = 1.04-6.00). Conclusion: This study suggests that the IL-1B C-31T polymorphism is associated with hypertension, and that this association is modulated by serum β-carotene levels.

AB - Background & aims: Recent studies have indicated a close relationship between hypertension and inflammation. Antioxidant substances, including β-carotene, are known to be preventive factors for hypertension. We investigated the effect of serum β-carotene levels on the association between the interleukin-1beta (IL-1B) C-31T polymorphism and hypertension. Methods: Subjects were 625 inhabitants (200 males and 425 females) of Japan, aged 39-70 years, who attended a health check-up examination in 2003. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting two-pair primers. Serum β-carotene levels were measured using high-performance liquid chromatography. Results: The TT genotype of IL-1B C-31T was associated with an increased risk of hypertension in all subjects (Odds Ratio [OR] = 1.82, 95% Confidence Interval [95% CI] = 1.09-3.06, compared with CC genotype). Among male CC carriers, those with high serum β-carotene levels had a significantly lower OR (OR = 0.25, 95% CI = 0.06-0.95) for hypertension relative to those with low serum β-carotene levels. The TT carriers had a significantly higher OR compared with the CC carriers among males with high serum β-carotene levels (OR = 5.03, 95% CI = 1.34-21.58) and among females with low serum β-carotene levels (OR = 2.47, 95% CI = 1.04-6.00). Conclusion: This study suggests that the IL-1B C-31T polymorphism is associated with hypertension, and that this association is modulated by serum β-carotene levels.

UR - http://www.scopus.com/inward/record.url?scp=63549084141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63549084141&partnerID=8YFLogxK

U2 - 10.1016/j.clnu.2009.01.020

DO - 10.1016/j.clnu.2009.01.020

M3 - Article

C2 - 19249142

AN - SCOPUS:63549084141

VL - 28

SP - 198

EP - 202

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 2

ER -