Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly

Shiori Toba, Yasuhisa Tamura, Kanako Kumamoto, Masami Yamada, Keizo Takao, Satoko Hattori, Tsuyoshi Miyakawa, Yosky Kataoka, Mitsuyoshi Azuma, Kiyoshi Hayasaka, Masano Amamoto, Keiko Tominaga, Anthony Wynshaw-Boris, Hideki Wanibuchi, Yuichiro Oka, Makoto Sato, Mitsuhiro Kato, Shinji Hirotsune

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1+/− mice, impaired behavioral performance and improvement of 18F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1+/− mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients.

本文言語English
論文番号1224
ページ(範囲)1-10
ページ数10
ジャーナルScientific reports
3
DOI
出版ステータスPublished - 06-02-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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