@article{f06556ffc07540dfb6d67e5fb0486351,
title = "Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly",
abstract = "Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1+/− mice, impaired behavioral performance and improvement of 18F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1+/− mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients.",
author = "Shiori Toba and Yasuhisa Tamura and Kanako Kumamoto and Masami Yamada and Keizo Takao and Satoko Hattori and Tsuyoshi Miyakawa and Yosky Kataoka and Mitsuyoshi Azuma and Kiyoshi Hayasaka and Masano Amamoto and Keiko Tominaga and Anthony Wynshaw-Boris and Hideki Wanibuchi and Yuichiro Oka and Makoto Sato and Mitsuhiro Kato and Shinji Hirotsune",
note = "Funding Information: We thank Azusa Inagaki, Kaori Nakakubo, Yukimi Kira and Yoriko Yabunaka for technical support, Hiromichi Nishimura and Keiko Fujimoto for mouse breeding. This work was supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan from the Ministry of Education, Science, Sports and Culture of Japan to Shinji Hirotsune and Knowledge Cluster Initiative (Stage-2) Research Foundation to Shinji Hirotsune. This work was also supported by Takeda Science Foundation and the Sumitomo Foundation to Shinji Hirotsune and NIH grants NS41030 and HD47380 to Anthony Wynshaw-Boris. This work was also supported in part by Grant-in-Aid for Scientific Research(B) of Japan Society for the Promotion of Science (JSPS)(\#22390056 to Masami Yamada), Adaptable and Seamless Technology Transfer Program (A-STEP) through Target-driven R\&D, Japan Science and Technology Agency (\#AS231Z02224G to Masami Yamada), Grant-in-Aid for Scientific Research on Innovative Areas of The Ministry of Education, Culture, Sports, Science and Technology (MEXT)(\#11001981 to Masami Yamada) and The Uehara Memorial Foundation (to Masami Yamada). This work was also supported by KAKENHI (Grant-in-Aid for Scientific Research) on Young Scientists A (16680015), Scientific Research (B) (21300121, 21390069), Exploratory Research (19653081), Integrative Brain Research (IBR-shien), and Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture of Japan (MEXT) of Japan, grant from Neuroinformatics Japan Center (NIJC), grants from CREST of Japan Science and Technology Agency (JST), and the Funding Program for Next Generation World-Leading Researchers (Next Program). This work was also supported by the Multidisciplinary program for elucidating the brain development from molecules to social behavior (Fukui Brain Project) and the Grants-in-Aid for Scientific Research and Strategic Research Program for Brain Sciences ({\textquoteleft}{\textquoteleft}integrated research on neuropsychiatric disorder{\textquoteright}{\textquoteright}) by the Ministry of Education, Culture, Sports, Science and Technology of Japan to Makoto Sato. We declare no conflicts of interests.",
year = "2013",
month = feb,
day = "6",
doi = "10.1038/srep01224",
language = "English",
volume = "3",
pages = "1--10",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Research",
}