抄録
We detected the transient coexistence of tyrosine hydroxylase (TH) and choline acetyltransferase (CAT) in the neurons of the dorsal motor nucleus of the vagus (DMV) and in cholinergic fibers of the myenteric plexus of the stomach of the laboratory shrew (Suncus murinus) by immunohistochemistry. The DMV neurons showed no reactivity to antiserum against GTP cyclohydrolase I, DOPA, aromatic L-amino acid decarboxylase or dopamine. After birth, the intensity of TH-immunoreactivity of the DMV neurons reached a maximum on postnatal days 7-9 and then decreased until postnatal day 20, when almost no TH-immunoreactivity was detected. These results suggest that TH may function not as a catecholamine-synthesizing enzyme but as a regulatory protein necessary for release acceleration or inhibition in the postnatal development of cholinergic neurons of the DMV.
本文言語 | 英語 |
---|---|
ページ(範囲) | 171-179 |
ページ数 | 9 |
ジャーナル | Biogenic Amines |
巻 | 13 |
号 | 3 |
出版ステータス | 出版済み - 1997 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 神経科学一般
- 薬理学