Potent small molecule mouse CD22-inhibitors: Exploring the interaction of the residue at C-2 of sialic acid scaffold

Hajjaj H.M. Abdu-Allah, Kozo Watanabe, Koji Hayashizaki, Chiaki Takaku, Taichi Tamanaka, Hiromu Takematsu, Yasunori Kozutsumi, Takeshi Tsubata, Hideharu Ishida, Makoto Kiso

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Our previous study revealed that compound 1 (9-(4′-hydroxy-4-biphenyl)acetamido-9-deoxy-Neu5Gcα2-6GalOMP) has the most promising affinity for mCD22. Replacing the subterminal galactose residue of 1 with benzyl or biphenylmethyl as aglycone led to 38- and 20-fold higher potency, respectively. This discovery represents a new direction in inhibitor design suitable for pharmaceutical development.

本文言語English
ページ(範囲)5573-5575
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
19
19
DOI
出版ステータスPublished - 01-10-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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