Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

Takuya Fujimoto; Tooru Andoh; Tamotsu Sudo; Ikuo Fujita; Naomasa Fukase; Tamotsu Takeuchi; Hiroshi Sonobe; Masayoshi Inoue; Tkanori Hirose; Toshiko Sakuma; Hiroshi Moritake; Tohru Sugimoto; Teruya Kawamoto; Yoshinobu Fukumori; Satomi Yamamoto; Shinji Atagi; Yoshinori Sakurai; Masahiro Kurosaka; Koji Ono; Hideki Ichikawa; Minoru Suzuki

doi:10.1016/j.apradiso.2015.07.059

Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

Takuya Fujimoto
, Tooru Andoh
, Tamotsu Sudo
, Ikuo Fujita
, Naomasa Fukase
, Tamotsu Takeuchi
, Hiroshi Sonobe
, Masayoshi Inoue
, Tkanori Hirose
, Toshiko Sakuma
, Hiroshi Moritake
, Tohru Sugimoto
, Teruya Kawamoto
, Yoshinobu Fukumori
, Satomi Yamamoto
, Shinji Atagi
, Yoshinori Sakurai
, Masahiro Kurosaka
, Koji Ono
, Hideki Ichikawa

Minoru Suzuki

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

抄録

Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-_L-phenylalanine (_L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.

本文言語	英語
ページ（範囲）	220-225
ページ数	6
ジャーナル	Applied Radiation and Isotopes
巻	106
DOI	https://doi.org/10.1016/j.apradiso.2015.07.059
出版ステータス	出版済み - 01-12-2015
外部発表	はい

All Science Journal Classification (ASJC) codes

放射線

文献へのアクセス

10.1016/j.apradiso.2015.07.059

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引用スタイル

Fujimoto, T., Andoh, T., Sudo, T., Fujita, I., Fukase, N., Takeuchi, T., Sonobe, H., Inoue, M., Hirose, T., Sakuma, T., Moritake, H., Sugimoto, T., Kawamoto, T., Fukumori, Y., Yamamoto, S., Atagi, S., Sakurai, Y., Kurosaka, M., Ono, K., ... Suzuki, M. (2015). Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST). Applied Radiation and Isotopes, 106, 220-225. https://doi.org/10.1016/j.apradiso.2015.07.059

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title = "Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)",

abstract = "Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.",

author = "Takuya Fujimoto and Tooru Andoh and Tamotsu Sudo and Ikuo Fujita and Naomasa Fukase and Tamotsu Takeuchi and Hiroshi Sonobe and Masayoshi Inoue and Tkanori Hirose and Toshiko Sakuma and Hiroshi Moritake and Tohru Sugimoto and Teruya Kawamoto and Yoshinobu Fukumori and Satomi Yamamoto and Shinji Atagi and Yoshinori Sakurai and Masahiro Kurosaka and Koji Ono and Hideki Ichikawa and Minoru Suzuki",

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doi = "10.1016/j.apradiso.2015.07.059",

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Fujimoto, T, Andoh, T, Sudo, T, Fujita, I, Fukase, N, Takeuchi, T, Sonobe, H, Inoue, M, Hirose, T, Sakuma, T, Moritake, H, Sugimoto, T, Kawamoto, T, Fukumori, Y, Yamamoto, S, Atagi, S, Sakurai, Y, Kurosaka, M, Ono, K, Ichikawa, H & Suzuki, M 2015, 'Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)', Applied Radiation and Isotopes, vol. 106, pp. 220-225. https://doi.org/10.1016/j.apradiso.2015.07.059

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T1 - Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

AU - Fujimoto, Takuya

AU - Andoh, Tooru

AU - Sudo, Tamotsu

AU - Fujita, Ikuo

AU - Fukase, Naomasa

AU - Takeuchi, Tamotsu

AU - Sonobe, Hiroshi

AU - Inoue, Masayoshi

AU - Hirose, Tkanori

AU - Sakuma, Toshiko

AU - Moritake, Hiroshi

AU - Sugimoto, Tohru

AU - Kawamoto, Teruya

AU - Fukumori, Yoshinobu

AU - Yamamoto, Satomi

AU - Atagi, Shinji

AU - Sakurai, Yoshinori

AU - Kurosaka, Masahiro

AU - Ono, Koji

AU - Ichikawa, Hideki

AU - Suzuki, Minoru

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.

AB - Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.

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AN - SCOPUS:84959465576

SN - 0969-8043

VL - 106

SP - 220

EP - 225

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

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