Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b

Yoshimasa Hashimoto, Hidenori Ochi, Hiromi Abe, Yasufumi Hayashida, Masataka Tsuge, Fukiko Mitsui, Nobuhiko Hiraga, Michio Imamura, Shoichi Takahashi, C. Nelson Hayes, Waka Ohishi, Michiaki Kubo, Tatsuhiko Tsunoda, Naoyuki Kamatani, Yusuke Nakamura, Kazuaki Chayama

研究成果: Article

11 引用 (Scopus)

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Variation at the IL-28B locus was recently reported to be a significant predictive factor of viral response to pegylated-interferon plus ribavirin combination therapy against chronic hepatitis C. Predictive factors for the effect of therapy, including IL-28B polymorphism rs8099917 and viral and clinical factors were investigated. A total of 288 patients were enrolled who were chronically infected with hepatitis C virus (HCV) genotype 1b and treated with combination therapy. Among them, 87 patients completed 48 weeks of therapy without dose reduction or discontinuation. In multivariate regression analysis, the rs8099917 TT genotype was the only independent factor significantly associated with sustained viral response (P=0.016, OR 61.5), whereas substitutions at amino acid 70 (aa 70) of the HCV core protein (P=0.038, OR 5.9) and non-TT genotypes (P=0.002, OR 17.2) were associated with nonvirological response. Both factors were also associated with viral dynamics during the initial stage of the therapy. Correlation analysis revealed that rs8099917 genotype was correlated with γ-glutamyl transpeptidase, hyaluronic acid, and HCV core aa 70. In conclusion, host (IL-28B polymorphism) and viral (aa 70) factors independently affect response to combination therapy.

元の言語English
ページ(範囲)981-988
ページ数8
ジャーナルJournal of Medical Virology
83
発行部数6
DOI
出版物ステータスPublished - 01-06-2011

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

これを引用

Hashimoto, Y., Ochi, H., Abe, H., Hayashida, Y., Tsuge, M., Mitsui, F., Hiraga, N., Imamura, M., Takahashi, S., Nelson Hayes, C., Ohishi, W., Kubo, M., Tsunoda, T., Kamatani, N., Nakamura, Y., & Chayama, K. (2011). Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b. Journal of Medical Virology, 83(6), 981-988. https://doi.org/10.1002/jmv.22028