Present and future of reverse genetics of rotavirus

研究成果: Review article

抜粋

Rotavirus is the leading pathogen for acute gastroenteritis in mammals and birds. Although the reverse genetics system has been utilized in many viruses, the system using a helper virus was developed for rotavirus in 2006. As a step for antigenic analysis of VP4 antigen of rotavirus, we prepared an infectious rotavirus with a spike protein VP4 having an antigenic mosaic by substituting one of the cross-reactive neutralization epitopes of a simian strain SA-11 with the corresponding one of a human strain DS-1. The future improvement and application of the rotavirus reverse genetics were discussed in this review.

元の言語English
ページ(範囲)91-98
ページ数8
ジャーナルUirusu. Journal of virology
59
発行部数1
DOI
出版物ステータスPublished - 06-2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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