Prevalence of small for gestational age (SGA) and short stature in children born SGA who qualify for growth hormone treatment at 3 years of age: Population-based study

Kaori Fujita, Miwako Nagasaka, Sota Iwatani, Tsubasa Koda, Daisuke Kurokawa, Keiji Yamana, Kosuke Nishida, Mariko Taniguchi-Ikeda, Eiko Uchino, Chika Shirai, Kazumoto Iijima, Ichiro Morioka

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Background: To treat children born small for gestational age (SGA) with severe short stature, treatment with growth hormone (GH) has been approved in the USA, Europe, and Japan, but no population-based studies have reported their prevalence. The aims of this study were to investigate the prevalence of SGA and short stature in children born SGA who qualify for GH treatment at 3 years of age in a Japanese population. Methods: A population-based study was conducted in Kobe, Japan with 27 228 infants who were born between 2006 and 2008 and followed until 3 years of age. Prevalence of birthweight (BW) or birth length (BL) ≤ −2.0 standard deviation scores (SDS) for gestational age (GA; definition of SGA) was calculated. Short children born SGA who qualify for GH treatment at 3 years of age were estimated using the following criteria: BW and BL below the 10th percentile for GA, BW or BL ≤ −2.0 SDS for GA, and 2.5 SDS below the mean height for age. Results: The prevalence of SGA was 3.5%. The estimated prevalence of short stature in children born SGA who met the criteria for GH treatment was 0.06%. The prevalence in infants born <34 weeks (0.39%) was significantly higher than that in infants born 34–41 weeks GA (0.05%, P = 0.02). Conclusions: The prevalence of SGA and short stature in children born SGA who qualify for GH treatment is approximately 1 of 30 infants and 1 of 1800 children, respectively. The risk is increased when children are born <34 weeks GA.

本文言語English
ページ(範囲)372-376
ページ数5
ジャーナルPediatrics International
58
5
DOI
出版ステータスPublished - 01-05-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康

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