Preventive role of regular low-intensity exercise during adolescence in schizophrenia model mice with abnormal behaviors

Hikaru Koizumi, Taichi Hiraga, Leandro K. Oharomari, Toshiaki Hata, Takeru Shima, Jang Soo Yook, Masahiro Okamoto, Akihiro Mouri, Toshitaka Nabeshima, Hideaki Soya

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Schizophrenia is probably ascribed to perinatal neurodevelopmental deficits, and its onset might be affected by environmental factors. Hypofrontality with glutamatergic and dopaminergic neuronal dysfunction are known factors, but a way to mitigate abnormalities remains unfound. An early enriched environment such as a wheel running in rodents may contribute to the prevention, but its clinical applicability is very limited. From our studies, low-intensity exercise training (LET) based on physiological indices, such as lactate threshold, easily translates to humans and positively affects the brains. Hence, LET during adolescence may ameliorate abnormalities in neurodevelopment and prevent the development of schizophrenia. In the current study, LET prevented sensitization to phencyclidine (PCP) treatment, impairment of cognition, and affective behavioral abnormalities in an animal model of schizophrenia induced by prenatal PCP treatment. Further, LET increased dopamine turnover and attenuated the impairment of phosphorylation of ERK1/2 after exposure to a novel object in the prenatal PCP-treated mice. These results suggest that LET during adolescence completely improves schizophrenia-like abnormal behaviors associated with improved glutamate uptake and the dopamine-induced ERK1/2 signaling pathway in the PFC.

本文言語English
ページ(範囲)610-616
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
534
DOI
出版ステータスPublished - 01-01-2021

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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