Primary lateral sclerosis presenting parkinsonian symptoms without nigrostriatal involvement

N. Mabuchi, H. Watanabe, N. Atsuta, M. Hirayama, H. Ito, H. Fukatsu, T. Kato, K. Ito, G. Sobue

研究成果: Article査読

18 被引用数 (Scopus)

抄録

We encountered three patients with primary lateral sclerosis (PLS) showing bradykinesia, frozen gait, and severe postural instability, as well as slowly progressive spinobulbar spasticity. Cranial magnetic resonance (MR) imaging showed precentral gyrus atrophy. Central motor conduction was markedly prolonged or failed to evoke a response. Positron emission tomography (PET) showed significant reduction of [18F]fluoro-2-deoxy-D-glucose uptake in the area of the precentral gyrus extending to the prefrontal, medial frontal, and cingulate areas. No abnormalities were seen in the nigrostriatal system with PET using [18F]fluorodopa or [11C]raclopride or with proton MR spectroscopy. Thus, widespread prefrontal, medial, and cingulate frontal lobe involvement can be associated with the parkinsonian symptoms in PLS.

本文言語English
ページ(範囲)1768-1771
ページ数4
ジャーナルJournal of Neurology, Neurosurgery and Psychiatry
75
12
DOI
出版ステータスPublished - 12-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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