Primary low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma with polypoid appearance. Polypoid gastric MALT lymphoma: A clinicopathologic study of eight cases

Takio Yokoi, Tsuneya Nakamura, Kunio Kasugai, Yasushi Yatabe, Masahiro Fujita, Makoto Kuroda, Kayoko Akaza, Chisa Nomura, Eiji Hamajima, Taizan Suchi, Masao Seto, Kazuo Hara, Shigeo Nakamura

研究成果: Article査読

17 被引用数 (Scopus)

抄録

In the current study, we report eight cases with primary low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma endoscopically characterized by polypoid lesions in order to highlight their clinicopathologic significance. Four patients were male, their ages ranging from 40 to 78 years old. The resected specimens revealed a histology of low- grade MALT lymphoma characterized by dense lymphocytic infiltration predominantly in the submucosa and a relatively monotonous proliferation of centrocyte-like cells with reactive follicles and infrequent lymphoepithelial lesions. The tumor cells were of CD5-, CD10-, CD20+, BCL2+ and cycline D1- phenotype, and showed a monoclonal rearrangement of immunoglobulin heavy chain genes in the five of six cases examined. Interestingly, Helicobacter pylori (H. pylori) was detected in three (37.5%) of the eight patients, which was significantly lower than previous reports. Two of the H. pylori-positive cases initially underwent H. pylori eradication, but showed no change in their lymphomas after the cure of H. pylori infection. The clinicopathologic findings of the present cases appeared to closely resemble those of colorectal MALT lymphoma with a polypoid appearance and few association of H. pylori infection in their pathogenesis. These gastric polypoid cases may merit separate consideration because of the therapeutic problems they pose.

本文言語English
ページ(範囲)702-709
ページ数8
ジャーナルPathology International
49
8
DOI
出版ステータスPublished - 1999

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

フィンガープリント 「Primary low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma with polypoid appearance. Polypoid gastric MALT lymphoma: A clinicopathologic study of eight cases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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