抜粋
Neurotrophins are synthesized as precursors called pro-neurotrophins and then mature neurotrophins are formed proteolytically from them. Recent findings revealed that pro- and mature neurotrophins elicit opposite functional effects on cell survival, highlighting the importance of this processing step. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the neurotrophin family and are mutually homologous, but BDNF is less efficiently processed. In order to find the reason for this, we examined some possibilities by using PC12 cells, and found that the pro-region, especially the last half of it, affected very much the processing efficiency of these neurotrophins.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 919-924 |
| ページ数 | 6 |
| ジャーナル | Biochemical and Biophysical Research Communications |
| 巻 | 356 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | Published - 18-05-2007 |
| 外部発表 | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Biophysics
- Molecular Biology
フィンガープリント Pro-region of neurotrophins determines the processing efficiency' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Nomoto, H., Takaiwa, M., Mouri, A., & Furukawa, S. (2007). Pro-region of neurotrophins determines the processing efficiency. Biochemical and Biophysical Research Communications, 356(4), 919-924. https://doi.org/10.1016/j.bbrc.2007.03.059