抄録
Neurotrophins are synthesized as precursors called pro-neurotrophins and then mature neurotrophins are formed proteolytically from them. Recent findings revealed that pro- and mature neurotrophins elicit opposite functional effects on cell survival, highlighting the importance of this processing step. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the neurotrophin family and are mutually homologous, but BDNF is less efficiently processed. In order to find the reason for this, we examined some possibilities by using PC12 cells, and found that the pro-region, especially the last half of it, affected very much the processing efficiency of these neurotrophins.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 919-924 |
| ページ数 | 6 |
| ジャーナル | Biochemical and Biophysical Research Communications |
| 巻 | 356 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | Published - 18-05-2007 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Biophysics
- Molecular Biology
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Pro-region of neurotrophins determines the processing efficiency. / Nomoto, Hiroshi; Takaiwa, Masatoshi; Mouri, Akihiro; Furukawa, Shoei.
：: Biochemical and Biophysical Research Communications, 巻 356, 番号 4, 18.05.2007, p. 919-924.研究成果: Article
TY - JOUR
T1 - Pro-region of neurotrophins determines the processing efficiency
AU - Nomoto, Hiroshi
AU - Takaiwa, Masatoshi
AU - Mouri, Akihiro
AU - Furukawa, Shoei
PY - 2007/5/18
Y1 - 2007/5/18
N2 - Neurotrophins are synthesized as precursors called pro-neurotrophins and then mature neurotrophins are formed proteolytically from them. Recent findings revealed that pro- and mature neurotrophins elicit opposite functional effects on cell survival, highlighting the importance of this processing step. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the neurotrophin family and are mutually homologous, but BDNF is less efficiently processed. In order to find the reason for this, we examined some possibilities by using PC12 cells, and found that the pro-region, especially the last half of it, affected very much the processing efficiency of these neurotrophins.
AB - Neurotrophins are synthesized as precursors called pro-neurotrophins and then mature neurotrophins are formed proteolytically from them. Recent findings revealed that pro- and mature neurotrophins elicit opposite functional effects on cell survival, highlighting the importance of this processing step. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the neurotrophin family and are mutually homologous, but BDNF is less efficiently processed. In order to find the reason for this, we examined some possibilities by using PC12 cells, and found that the pro-region, especially the last half of it, affected very much the processing efficiency of these neurotrophins.
UR - http://www.scopus.com/inward/record.url?scp=34047185855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047185855&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2007.03.059
DO - 10.1016/j.bbrc.2007.03.059
M3 - Article
C2 - 17395157
AN - SCOPUS:34047185855
VL - 356
SP - 919
EP - 924
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -