Pro-region of neurotrophins determines the processing efficiency

Hiroshi Nomoto, Masatoshi Takaiwa, Akihiro Mouri, Shoei Furukawa

研究成果: Article

18 引用 (Scopus)

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Neurotrophins are synthesized as precursors called pro-neurotrophins and then mature neurotrophins are formed proteolytically from them. Recent findings revealed that pro- and mature neurotrophins elicit opposite functional effects on cell survival, highlighting the importance of this processing step. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the neurotrophin family and are mutually homologous, but BDNF is less efficiently processed. In order to find the reason for this, we examined some possibilities by using PC12 cells, and found that the pro-region, especially the last half of it, affected very much the processing efficiency of these neurotrophins.

元の言語English
ページ(範囲)919-924
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
356
発行部数4
DOI
出版物ステータスPublished - 18-05-2007
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

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