TY - JOUR
T1 - Probing, inhibition, and crystallographic characterization of metallo-β-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups
AU - Kurosaki, Hiromasa
AU - Yamaguchi, Yoshihiro
AU - Yasuzawa, Hisami
AU - Jin, Wanchun
AU - Yamagata, Yuriko
AU - Arakawa, Yoshichika
PY - 2006/9
Y1 - 2006/9
N2 - A series of fluorescent probes, N-(5-(dimethylamino)-1- naphthalenesulfonamido(alkyl)n)-3-thiopropionamide (DansylC nSHs), were rationally designed to detect and inhibit metallo-β-lactamase (IMP-1). These compounds were shown to function as fluorescent probes for and inhibitors of metallo-β-lactamases. The X-ray crystallographic structure shown indicates the potential of these agents for use as a new fluorescent probes for metallo-β-lactamases.
AB - A series of fluorescent probes, N-(5-(dimethylamino)-1- naphthalenesulfonamido(alkyl)n)-3-thiopropionamide (DansylC nSHs), were rationally designed to detect and inhibit metallo-β-lactamase (IMP-1). These compounds were shown to function as fluorescent probes for and inhibitors of metallo-β-lactamases. The X-ray crystallographic structure shown indicates the potential of these agents for use as a new fluorescent probes for metallo-β-lactamases.
UR - http://www.scopus.com/inward/record.url?scp=33749030701&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749030701&partnerID=8YFLogxK
U2 - 10.1002/cmdc.200600115
DO - 10.1002/cmdc.200600115
M3 - Article
C2 - 16937423
AN - SCOPUS:33749030701
SN - 1860-7179
VL - 1
SP - 969
EP - 972
JO - ChemMedChem
JF - ChemMedChem
IS - 9
ER -