TY - JOUR
T1 - Production and functions of IL-17 in microglia
AU - Kawanokuchi, Jun
AU - Shimizu, Kouki
AU - Nitta, Atsumi
AU - Yamada, Kiyofumi
AU - Mizuno, Tetsuya
AU - Takeuchi, Hideyuki
AU - Suzumura, Akio
PY - 2008/2
Y1 - 2008/2
N2 - Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1β. Because microglia produce IL-1β and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.
AB - Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1β. Because microglia produce IL-1β and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.
UR - http://www.scopus.com/inward/record.url?scp=39849092553&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39849092553&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2007.11.006
DO - 10.1016/j.jneuroim.2007.11.006
M3 - Article
C2 - 18164424
AN - SCOPUS:39849092553
SN - 0165-5728
VL - 194
SP - 54
EP - 61
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -