Production of murine collagen-induced arthritis using Klebsiella pneumoniae O3 lipopolysaccharide as a potent immunological adjuvant

Kazuko Takahashi, Yutaka Kato, Tsuyoshi Sugiyama, Naoki Koide, Makoto Kawai, Masako Fukada, Tomoaki Yoshida, Takashi Yokochi

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Collagen-induced arthritis (CIA) was produced in mice with non H-2(q) and H-2(r) haplotypes by repeated immunization of porcine type-II collagen (CH) together with Klebsiella O3 lipopolysaccharide (KO3 LPS) as an immunological adjuvant. Histological changes that appeared in joints of repeatedly immunized mice were characterized by destruction of normal joint structure, synovial hyperplasia with proliferation of synovial cells, and infiltration of inflammatory cells. No such lesions were produced in mice receiving repeated injections of CII alone or KO3 LPS alone. Development of the humoral antibody and the delayed-type hypersensitivity to CH was exclusively found in mice immunized with the mixture of CII and KO3 LPS. It was therefore suggested that arthritis lesions induced by repeated immunization with the mixture of CII and KO3 LPS might be caused by an autoimmune mechanism, and that the experimental model might be useful for characterization of human rheumatoid arthritis (RA).

本文言語English
ページ(範囲)795-801
ページ数7
ジャーナルMICROBIOLOGY and IMMUNOLOGY
43
8
DOI
出版ステータスPublished - 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 免疫学
  • ウイルス学

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