TY - JOUR
T1 - Prognostic scores for patients with salivary adenoid cystic carcinoma without lymph node metastasis
AU - Shimoda, Hikari
AU - Teshima, Masanori
AU - Murase, Takayuki
AU - Nagao, Toshitaka
AU - Kusafuka, Kimihide
AU - Nakaguro, Masato
AU - Urano, Makoto
AU - Taguchi, Ken ichi
AU - Yamamoto, Hidetaka
AU - Kano, Satoshi
AU - Tada, Yuichiro
AU - Tsukahara, Kiyoaki
AU - Okami, Kenji
AU - Onitsuka, Tetsuro
AU - Fujimoto, Yasushi
AU - Kawakita, Daisuke
AU - Sakurai, Kazuo
AU - Hanai, Nobuhiro
AU - Nagao, Toru
AU - Kawata, Ryo
AU - Hato, Naohito
AU - Nibu, Ken ichi
AU - Inagaki, Hiroshi
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/10
Y1 - 2023/10
N2 - Adenoid cystic carcinoma (AdCC) of salivary gland grows relatively slowly, but occasionally develops distant metastasis. Although cervical lymph node metastasis (LNM) has been reported as a strong prognostic factor, most of AdCC do not have LNM. In this study, we investigated the prognostic factors to predict disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS) for 175 patients surgically treated for AdCC without LNM, and developed prognostic score (PS) determined as number of positive prognostic factors. The following emerged as significant prognostic factors: positive surgical margin in DFS, pT3/4 and positive surgical margin in DMFS, and positive surgical margin and high-histological grade in OS. 10-year DFS rates were 56.4% in PS0, and 19.1% in PS1 (p < 0.0001). 10-year DMFS rates were 86.3% in PS0, 56.4% in PS1, and 30.7% in PS2 (p < 0.0001). 10-year OS rates were 100% in PS0, 73.3% in PS1, and 38.8% in PS2 (p < 0.0001).
AB - Adenoid cystic carcinoma (AdCC) of salivary gland grows relatively slowly, but occasionally develops distant metastasis. Although cervical lymph node metastasis (LNM) has been reported as a strong prognostic factor, most of AdCC do not have LNM. In this study, we investigated the prognostic factors to predict disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS) for 175 patients surgically treated for AdCC without LNM, and developed prognostic score (PS) determined as number of positive prognostic factors. The following emerged as significant prognostic factors: positive surgical margin in DFS, pT3/4 and positive surgical margin in DMFS, and positive surgical margin and high-histological grade in OS. 10-year DFS rates were 56.4% in PS0, and 19.1% in PS1 (p < 0.0001). 10-year DMFS rates were 86.3% in PS0, 56.4% in PS1, and 30.7% in PS2 (p < 0.0001). 10-year OS rates were 100% in PS0, 73.3% in PS1, and 38.8% in PS2 (p < 0.0001).
KW - And distant metastasis
KW - Lymph node metastasis
KW - Surgical margin
KW - minAmax
KW - pT
UR - https://www.scopus.com/pages/publications/85165573897
UR - https://www.scopus.com/pages/publications/85165573897#tab=citedBy
U2 - 10.1016/j.oraloncology.2023.106491
DO - 10.1016/j.oraloncology.2023.106491
M3 - Letter
C2 - 37487445
AN - SCOPUS:85165573897
SN - 1368-8375
VL - 145
JO - Oral Oncology
JF - Oral Oncology
M1 - 106491
ER -
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