Prognostic significance of a systemic inflammatory response in patients undergoing multimodality therapy for advanced colorectal cancer

Yasuhiro Inoue, Takashi Iwata, Yoshinaga Okugawa, Aya Kawamoto, Junichiro Hiro, Yuji Toiyama, Koji Tanaka, Keiichi Uchida, Yasuhiko Mohri, Chikao Miki, Masato Kusunoki

研究成果: Article査読

55 被引用数 (Scopus)

抄録

Objectives: The inflammation-based Glasgow Prognostic Score (GPS) is associated with outcome in a variety of cancers. This study investigated whether a modified GPS (mGPS) could predict survival in patients undergoing multimodality therapy for advanced colorectal cancer (CRC). Methods: We enrolled 245 patients with advanced CRC who received chemotherapy. The mGPS was recorded prior to first-line chemotherapy and to cytoreductive therapy including secondary surgery and/or radiofrequency ablation. The prognostic significance of the mGPS was analyzed using Kaplan-Meier, univariate, and multivariate analyses. Results: In patients who received chemotherapy alone (n = 163), the mGPS prior to chemotherapy was an independent prognostic indicator of survival [odds ratio (OR) 1.858; 95% confidence interval (CI) 1.213-2.846; p = 0.0044]. In patients who also underwent cytoreductive therapy (n = 82), the mGPS decreased after chemotherapy in 22 patients (27%) and increased in 5 (6%). In these patients, the mGPS prior to cytoreductive therapy was an independent prognostic indicator of survival (OR 3.412; 95% CI 1.198-9.720; p = 0.0216), but the mGPS prior to chemotherapy was not. Conclusions: The mGPS is an independent prognostic indicator of survival in patients undergoing multimodality therapy for advanced CRC, if recorded at a relevant time point.

本文言語English
ページ(範囲)100-107
ページ数8
ジャーナルOncology (Switzerland)
84
2
DOI
出版ステータスPublished - 12-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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