TY - JOUR
T1 - Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer
AU - Namikawa, Tsutomu
AU - Ishida, Nobuko
AU - Tsuda, Sachi
AU - Fujisawa, Kazune
AU - Munekage, Eri
AU - Iwabu, Jun
AU - Munekage, Masaya
AU - Uemura, Sunao
AU - Tsujii, Shigehiro
AU - Tamura, Takahiko
AU - Yatabe, Tomoaki
AU - Maeda, Hiromichi
AU - Kitagawa, Hiroyuki
AU - Kobayashi, Michiya
AU - Hanazaki, Kazuhiro
N1 - Publisher Copyright:
© 2018, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.
PY - 2019/7/12
Y1 - 2019/7/12
N2 - Background: This study evaluated the prognostic value of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) together with host-related factors in patients with unresectable advanced gastric cancer. Methods: The study enrolled 262 patients who received chemotherapy for unresectable advanced gastric cancer at Kochi Medical School from 2007 to 2015. Clinicopathological information and systemic inflammatory response data were analyzed for associations between baseline cancer-related prognostic variables and survival outcomes. Results: The median survival time was significantly lower for patients with high ALP, high LDH, high total bilirubin, high aspartate aminotransferase, high alanine transaminase, high gamma-glutamyltransferase, high creatinine, a Glasgow prognostic score (GPS) of 1 or 2 score compared to GPS 0, higher compared to lower neutrophil to lymphocyte ratio (NLR) 3.9, lower compared to higher prognostic nutrition index 36.1, T3–4 compared to T1–2 tumor and diffuse-type compared to intestinal-type histology. Multivariate survival analysis identified high ALP 322 (HR 1.808; 95% CI 1.015–3.220; P = 0.044), T2–3 (HR 2.622; 95% CI 1.224–5.618; P = 0.013), and diffuse-type gastric cancer (HR 2.325; 95% CI 1.341–4.032; P = 0.003) as significant independent predictors of worse prognosis in the studied group of cancer patients. Conclusions: High level of ALP is an independent, worse prognosis factor for patients receiving chemotherapy for unresectable and recurrent gastric cancer.
AB - Background: This study evaluated the prognostic value of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) together with host-related factors in patients with unresectable advanced gastric cancer. Methods: The study enrolled 262 patients who received chemotherapy for unresectable advanced gastric cancer at Kochi Medical School from 2007 to 2015. Clinicopathological information and systemic inflammatory response data were analyzed for associations between baseline cancer-related prognostic variables and survival outcomes. Results: The median survival time was significantly lower for patients with high ALP, high LDH, high total bilirubin, high aspartate aminotransferase, high alanine transaminase, high gamma-glutamyltransferase, high creatinine, a Glasgow prognostic score (GPS) of 1 or 2 score compared to GPS 0, higher compared to lower neutrophil to lymphocyte ratio (NLR) 3.9, lower compared to higher prognostic nutrition index 36.1, T3–4 compared to T1–2 tumor and diffuse-type compared to intestinal-type histology. Multivariate survival analysis identified high ALP 322 (HR 1.808; 95% CI 1.015–3.220; P = 0.044), T2–3 (HR 2.622; 95% CI 1.224–5.618; P = 0.013), and diffuse-type gastric cancer (HR 2.325; 95% CI 1.341–4.032; P = 0.003) as significant independent predictors of worse prognosis in the studied group of cancer patients. Conclusions: High level of ALP is an independent, worse prognosis factor for patients receiving chemotherapy for unresectable and recurrent gastric cancer.
UR - http://www.scopus.com/inward/record.url?scp=85056267907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056267907&partnerID=8YFLogxK
U2 - 10.1007/s10120-018-0897-8
DO - 10.1007/s10120-018-0897-8
M3 - Article
C2 - 30417313
AN - SCOPUS:85056267907
SN - 1436-3291
VL - 22
SP - 684
EP - 691
JO - Gastric Cancer
JF - Gastric Cancer
IS - 4
ER -
