PROKR2 is associated with methamphetamine dependence in the Japanese population

Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumura, Tomo Okochi, Kunihiro Kawashima, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

研究成果: Article

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Background: Many patients with drug addiction are reported to have comorbid mood disorders. One of the suggested pathophysiological mechanisms for mood disorders is disruption of circadian rhythms. Several animal studies have shown that methamphetamine altered the expression of circadian clock molecules in the brain. Therefore, it is possible that mood disorders and drug addiction have common susceptibility genes. Recently, we reported that the prokineticin 2 receptor gene (PROKR2) was associated with mood disorders including major depressive disorder and bipolar disorder in the Japanese population. In the present study, therefore, we conducted an association analysis of tagging SNPs in PROKR2 with Japanese methamphetamine dependence patients. Methods: Using five tagging SNPs in PROKR2, we conducted a genetic association analysis of case-control samples (199 methamphetamine dependence patients and 337 healthy controls). The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Results: We detected a significant association between PROKR2 and methamphetamine dependence patients in allele/genotype-wise and haplotype-wise analysis. Conclusion: Our results suggest that PROKR2 may play a role in the pathophysiology of methamphetamine dependence in the Japanese population. However, because we did not perform a mutation scan of PROKR2, a replication study using a larger sample may be required for conclusive results.

元の言語English
ページ(範囲)1033-1036
ページ数4
ジャーナルProgress in Neuro-Psychopharmacology and Biological Psychiatry
34
発行部数6
DOI
出版物ステータスPublished - 01-08-2010

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

これを引用

Kishi, T., Kitajima, T., Tsunoka, T., Okumura, T., Okochi, T., Kawashima, K., Inada, T., Ujike, H., Yamada, M., Uchimura, N., Sora, I., Iyo, M., Ozaki, N., & Iwata, N. (2010). PROKR2 is associated with methamphetamine dependence in the Japanese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(6), 1033-1036. https://doi.org/10.1016/j.pnpbp.2010.05.018