Proliferation and Neoplastic Transformation of Pigment Cells in Metallothionein/ret Transgenic Mice

MASAHIDE TAKAHASHI, TAKASHI IWAMOTO, IZUMI NAKASHIMA

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Although melanoma is a common human disease, there were few animal models in which melanoma developed at high incidence. To date, the Xiphophorus fish has been used as a model system to study melanoma formation. Studies on this fish showed the presence of a dominant oncogene, Tu, which encodes a transmembrane, tyrosine kinase of epidermal growth factor receptor type (Wittbrodt et al., Nature, 341:415–421, 1989). Recently, we succeeded in establishing novel transgenic mouse lines in which melanosis and melanocytic tumors developed stepwise by introducing another transmembrane tyrosine kinase oncogene, ret (Iwamoto et al., EMBO J., 10:3167–3175, 1991). In our transgenic mice, high levels of expression of the ret transgene induced proliferation and neoplastic transformation of melanin‐producing cells. In addition, crossbreeding experiments between transgenic mice and Wv mice showed that the ret oncogene can also induce melanogenesis and melanocyte development in Wv/Wv mice.

本文言語English
ページ(範囲)344-347
ページ数4
ジャーナルPigment Cell Research
5
5
DOI
出版ステータスPublished - 11-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 農業および作物学
  • 植物科学
  • 発生生物学
  • 臨床生化学
  • 細胞生物学

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