Prolonged selective neutropenia after allogeneic bone marrow transplantation: Possible effect of presensitization by donor lymphocytes prior to transplant

Masayuki Towatari, Koichi Miyamura, Yoshiki Akatsuka, Kazuhito Yamamoto, Saburo Minami, Yoshihisa Kodera

研究成果: Article

抄録

Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.

元の言語English
ページ(範囲)513-516
ページ数4
ジャーナルInternational Journal of Hematology
66
発行部数4
出版物ステータスPublished - 01-12-1997
外部発表Yes

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Homologous Transplantation
Neutropenia
Bone Marrow Transplantation
Chimerism
Tissue Donors
Lymphocytes
Transplants
Aplastic Anemia
Whole-Body Irradiation
Cytogenetic Analysis
Myeloid Cells
Immunosuppressive Agents
Anemia
Siblings
Immunity
Neutrophils
Bone Marrow
Conditioning (Psychology)

All Science Journal Classification (ASJC) codes

  • Hematology

これを引用

Towatari, Masayuki ; Miyamura, Koichi ; Akatsuka, Yoshiki ; Yamamoto, Kazuhito ; Minami, Saburo ; Kodera, Yoshihisa. / Prolonged selective neutropenia after allogeneic bone marrow transplantation : Possible effect of presensitization by donor lymphocytes prior to transplant. :: International Journal of Hematology. 1997 ; 巻 66, 番号 4. pp. 513-516.
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abstract = "Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.",
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Prolonged selective neutropenia after allogeneic bone marrow transplantation : Possible effect of presensitization by donor lymphocytes prior to transplant. / Towatari, Masayuki; Miyamura, Koichi; Akatsuka, Yoshiki; Yamamoto, Kazuhito; Minami, Saburo; Kodera, Yoshihisa.

:: International Journal of Hematology, 巻 66, 番号 4, 01.12.1997, p. 513-516.

研究成果: Article

TY - JOUR

T1 - Prolonged selective neutropenia after allogeneic bone marrow transplantation

T2 - Possible effect of presensitization by donor lymphocytes prior to transplant

AU - Towatari, Masayuki

AU - Miyamura, Koichi

AU - Akatsuka, Yoshiki

AU - Yamamoto, Kazuhito

AU - Minami, Saburo

AU - Kodera, Yoshihisa

PY - 1997/12/1

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AB - Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.

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