抄録
Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 513-516 |
| ページ数 | 4 |
| ジャーナル | International Journal of Hematology |
| 巻 | 66 |
| 発行部数 | 4 |
| 出版物ステータス | Published - 01-12-1997 |
| 外部発表 | Yes |
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All Science Journal Classification (ASJC) codes
- Hematology
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Prolonged selective neutropenia after allogeneic bone marrow transplantation : Possible effect of presensitization by donor lymphocytes prior to transplant. / Towatari, Masayuki; Miyamura, Koichi; Akatsuka, Yoshiki; Yamamoto, Kazuhito; Minami, Saburo; Kodera, Yoshihisa.
：: International Journal of Hematology, 巻 66, 番号 4, 01.12.1997, p. 513-516.研究成果: Article
TY - JOUR
T1 - Prolonged selective neutropenia after allogeneic bone marrow transplantation
T2 - Possible effect of presensitization by donor lymphocytes prior to transplant
AU - Towatari, Masayuki
AU - Miyamura, Koichi
AU - Akatsuka, Yoshiki
AU - Yamamoto, Kazuhito
AU - Minami, Saburo
AU - Kodera, Yoshihisa
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.
AB - Selective neutropenia lasting over five months occurred in a 17-year- old adolescent male who received all allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling for severe aplastic anemia. Bone marrow specimens showed maturation arrest of myeloid precursor cells despite sustained engraftment. Cytogenetic analyses revealed complete donor-type chimerism in hematopoietic cells and mixed lymphoid chimerism. The patient received a second BMT from the same donor following more intensive conditioning, including total body irradiation. neutrophil recovery was rapid and complete donor-type hematopoietic and lymphoid chimerism was observed within three weeks of the second transplant. The present case suggests that prolonged selective neutropenia following BMT is due to residual host- derived immunity which is resistant to the standard immunosuppressive conditioning used prior to BMT for asplastic anemia.
UR - http://www.scopus.com/inward/record.url?scp=0031404733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031404733&partnerID=8YFLogxK
M3 - Article
C2 - 9479877
AN - SCOPUS:0031404733
VL - 66
SP - 513
EP - 516
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 4
ER -