Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with helicobacter pylori infection and gastric cancer occurrence

Tomomitsu Tahara, Tomoyuki Shibata, Hiromi Yamashita, Daisuke Yoshioka, Ichiro Hirata, Tomiyasu Arisawa

研究成果: Article

7 引用 (Scopus)

抜粋

We investigated the methylation status of multidrug resistance 1 (MDR1) gene promoter in noncancerous gastric mucosa in relation to gastric cancer (GC) occurrence. Methylation of the MDR1 promoter was estimated in 127 GC and 82 non-GC patients. A significant association was found between higher methylation ratio and occurrence of GC. Higher methylation ratio was also associated with occurrence of GC in both Helicobacter pyloripositive and Helicobacter pylorinegative subjects. Higher MR was also associated with Helicobacter pylori infection. Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence.

元の言語English
ページ(範囲)711-716
ページ数6
ジャーナルCancer Investigation
28
発行部数7
DOI
出版物ステータスPublished - 01-07-2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with helicobacter pylori infection and gastric cancer occurrence' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用