Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population

Tomiyasu Arisawa, Tomomitsu Tahara, Tomoyuki Shibata, Mitsuo Nagasaka, Masakatsu Nakamura, Yoshio Kamiya, Hiroshi Fujita, Daisuke Yoshioka, Masaaki Okubo, Mikiju Sakata, Fang Yu Wang, Ichiro Hirata, Hiroshi Nakano

研究成果: Article

1 引用 (Scopus)

抄録

Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) aggravate or ameliorate clinical disease activity in patients with ulcerative colitis (UC). UC is associated with increased local production of prostanoids. This study attempted to clarify the relationship between cyclooxygenase-1 (COX1) gene polymorphisms (T-1676C and A-842G/C50T) and ulcerative colitis in a Japanese population. Methodology: The study was performed on 108 patients with UC (mean age: 39.1 years, M:F=56:52) and 293 healthy controls (mean age: 49.0 years, M:F=161:132). The PCR-SSCP method was employed to detect COX1 polymorphisms using DNA extracted from peripheral blood cells. Results: No A-842G/C50T polymorphism was detected in all 401 Japanese subjects. The frequency of -1676C allele of COX1 gene in HC group and UC group was 48.8% and 48.1%, respectively. T-1676C genotypes of COX1 did not show significant association with UC risk. In addition, these genotypes were not also associated with the clinicopathological parameters of UC. Conclusions: This research suggests that COX1 promoter polymorphisms (T-1676C and A-842G/C50T) may not be associated with the risk of developing ulcerative colitis in a Japanese population.

元の言語English
ページ(範囲)987-990
ページ数4
ジャーナルHepato-gastroenterology
55
発行部数84
出版物ステータスPublished - 01-05-2008

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Cyclooxygenase 1
Ulcerative Colitis
Population
Genotype
Single-Stranded Conformational Polymorphism
Gene Frequency
Genes
Prostaglandins
Blood Cells
Anti-Inflammatory Agents
Polymerase Chain Reaction
DNA

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

これを引用

Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., ... Nakano, H. (2008). Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population. Hepato-gastroenterology, 55(84), 987-990.
Arisawa, Tomiyasu ; Tahara, Tomomitsu ; Shibata, Tomoyuki ; Nagasaka, Mitsuo ; Nakamura, Masakatsu ; Kamiya, Yoshio ; Fujita, Hiroshi ; Yoshioka, Daisuke ; Okubo, Masaaki ; Sakata, Mikiju ; Wang, Fang Yu ; Hirata, Ichiro ; Nakano, Hiroshi. / Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population. :: Hepato-gastroenterology. 2008 ; 巻 55, 番号 84. pp. 987-990.
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title = "Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population",
abstract = "Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) aggravate or ameliorate clinical disease activity in patients with ulcerative colitis (UC). UC is associated with increased local production of prostanoids. This study attempted to clarify the relationship between cyclooxygenase-1 (COX1) gene polymorphisms (T-1676C and A-842G/C50T) and ulcerative colitis in a Japanese population. Methodology: The study was performed on 108 patients with UC (mean age: 39.1 years, M:F=56:52) and 293 healthy controls (mean age: 49.0 years, M:F=161:132). The PCR-SSCP method was employed to detect COX1 polymorphisms using DNA extracted from peripheral blood cells. Results: No A-842G/C50T polymorphism was detected in all 401 Japanese subjects. The frequency of -1676C allele of COX1 gene in HC group and UC group was 48.8{\%} and 48.1{\%}, respectively. T-1676C genotypes of COX1 did not show significant association with UC risk. In addition, these genotypes were not also associated with the clinicopathological parameters of UC. Conclusions: This research suggests that COX1 promoter polymorphisms (T-1676C and A-842G/C50T) may not be associated with the risk of developing ulcerative colitis in a Japanese population.",
author = "Tomiyasu Arisawa and Tomomitsu Tahara and Tomoyuki Shibata and Mitsuo Nagasaka and Masakatsu Nakamura and Yoshio Kamiya and Hiroshi Fujita and Daisuke Yoshioka and Masaaki Okubo and Mikiju Sakata and Wang, {Fang Yu} and Ichiro Hirata and Hiroshi Nakano",
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Arisawa, T, Tahara, T, Shibata, T, Nagasaka, M, Nakamura, M, Kamiya, Y, Fujita, H, Yoshioka, D, Okubo, M, Sakata, M, Wang, FY, Hirata, I & Nakano, H 2008, 'Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population', Hepato-gastroenterology, 巻. 55, 番号 84, pp. 987-990.

Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population. / Arisawa, Tomiyasu; Tahara, Tomomitsu; Shibata, Tomoyuki; Nagasaka, Mitsuo; Nakamura, Masakatsu; Kamiya, Yoshio; Fujita, Hiroshi; Yoshioka, Daisuke; Okubo, Masaaki; Sakata, Mikiju; Wang, Fang Yu; Hirata, Ichiro; Nakano, Hiroshi.

:: Hepato-gastroenterology, 巻 55, 番号 84, 01.05.2008, p. 987-990.

研究成果: Article

TY - JOUR

T1 - Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population

AU - Arisawa, Tomiyasu

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Nagasaka, Mitsuo

AU - Nakamura, Masakatsu

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Sakata, Mikiju

AU - Wang, Fang Yu

AU - Hirata, Ichiro

AU - Nakano, Hiroshi

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) aggravate or ameliorate clinical disease activity in patients with ulcerative colitis (UC). UC is associated with increased local production of prostanoids. This study attempted to clarify the relationship between cyclooxygenase-1 (COX1) gene polymorphisms (T-1676C and A-842G/C50T) and ulcerative colitis in a Japanese population. Methodology: The study was performed on 108 patients with UC (mean age: 39.1 years, M:F=56:52) and 293 healthy controls (mean age: 49.0 years, M:F=161:132). The PCR-SSCP method was employed to detect COX1 polymorphisms using DNA extracted from peripheral blood cells. Results: No A-842G/C50T polymorphism was detected in all 401 Japanese subjects. The frequency of -1676C allele of COX1 gene in HC group and UC group was 48.8% and 48.1%, respectively. T-1676C genotypes of COX1 did not show significant association with UC risk. In addition, these genotypes were not also associated with the clinicopathological parameters of UC. Conclusions: This research suggests that COX1 promoter polymorphisms (T-1676C and A-842G/C50T) may not be associated with the risk of developing ulcerative colitis in a Japanese population.

AB - Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) aggravate or ameliorate clinical disease activity in patients with ulcerative colitis (UC). UC is associated with increased local production of prostanoids. This study attempted to clarify the relationship between cyclooxygenase-1 (COX1) gene polymorphisms (T-1676C and A-842G/C50T) and ulcerative colitis in a Japanese population. Methodology: The study was performed on 108 patients with UC (mean age: 39.1 years, M:F=56:52) and 293 healthy controls (mean age: 49.0 years, M:F=161:132). The PCR-SSCP method was employed to detect COX1 polymorphisms using DNA extracted from peripheral blood cells. Results: No A-842G/C50T polymorphism was detected in all 401 Japanese subjects. The frequency of -1676C allele of COX1 gene in HC group and UC group was 48.8% and 48.1%, respectively. T-1676C genotypes of COX1 did not show significant association with UC risk. In addition, these genotypes were not also associated with the clinicopathological parameters of UC. Conclusions: This research suggests that COX1 promoter polymorphisms (T-1676C and A-842G/C50T) may not be associated with the risk of developing ulcerative colitis in a Japanese population.

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