Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases

Qu Liu; Wanguang Zhang; Joseph J. Zhao; Nicholas L. Syn; Federica Cipriani; Mohammad Alzoubi; Davit L. Aghayan; Tiing Foong Siow; Chetana Lim; Olivier Scatton; Paulo Herman; Fabricio Ferreira Coelho; Marco V. Marino; Vincenzo Mazzaferro; Adrian K.H. Chiow; Iswanto Sucandy; Arpad Ivanecz; Sung Hoon Choi; Jae Hoon Lee; Mikel Prieto; Marco Vivarelli; Felice Giuliante; Bernardo Dalla Valle; Andrea Ruzzenente; Chee Chien Yong; Zewei Chen; Mengqiu Yin; Constantino Fondevila; Mikhail Efanov; Zenichi Morise; Fabrizio Di Benedetto; Raffaele Brustia; Raffaele Dalla Valle; Ugo Boggi; David Geller; Andrea Belli; Riccardo Memeo; Salvatore Gruttadauria; Alejandro Mejia; James O. Park; Fernando Rotellar; Gi Hong Choi; Ricardo Robles-Campos; Xiaoying Wang; Robert P. Sutcliffe; Moritz Schmelzle; Johann Pratschke; Chung Ngai Tang; Charing C.N. Chong; Kit Fai Lee; Juul Meurs; Mathieu D'Hondt; Kazuteru Monden; Santiago Lopez-Ben; Thomas Peter Kingham; Alessandro Ferrero; Giuseppe Maria Ettorre; Giovanni Battista Levi Sandri; Mansour Saleh; Daniel Cherqui; Junhao Zheng; Xiao Liang; Alessandro Mazzotta; Olivier Soubrane; Go Wakabayashi; Roberto I. Troisi; Tan To Cheung; Yutaro Kato; Atsushi Sugioka; Mizelle D'Silva; Ho Seong Han; Phan Phuoc Nghia; Tran Cong Duy Long; Bjørn Edwin; David Fuks; Kuo Hsin Chen; Mohammad Abu Hilal; Luca Aldrighetti; Rong Liu; Brian K.P. Goh

doi:10.1097/SLA.0000000000005855

Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases

Qu Liu, Wanguang Zhang, Joseph J. Zhao, Nicholas L. Syn, Federica Cipriani, Mohammad Alzoubi, Davit L. Aghayan, Tiing Foong Siow, Chetana Lim, Olivier Scatton, Paulo Herman, Fabricio Ferreira Coelho, Marco V. Marino, Vincenzo Mazzaferro, Adrian K.H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel PrietoMarco Vivarelli, Felice Giuliante, Bernardo Dalla Valle, Andrea Ruzzenente, Chee Chien Yong, Zewei Chen, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Salvatore Gruttadauria, Alejandro Mejia, James O. Park, Fernando Rotellar, Gi Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Moritz Schmelzle, Johann Pratschke, Chung Ngai Tang, Charing C.N. Chong, Kit Fai Lee, Juul Meurs, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Thomas Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Giovanni Battista Levi Sandri, Mansour Saleh, Daniel Cherqui, Junhao Zheng, Xiao Liang, Alessandro Mazzotta, Olivier Soubrane, Go Wakabayashi, Roberto I. Troisi, Tan To Cheung, Yutaro Kato, Atsushi Sugioka, Mizelle D'Silva, Ho Seong Han, Phan Phuoc Nghia, Tran Cong Duy Long, Bjørn Edwin, David Fuks, Kuo Hsin Chen, Mohammad Abu Hilal, Luca Aldrighetti, Rong Liu, Brian K.P. Goh

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

22 被引用数 (Scopus)

抄録

Objective: To compare the outcomes between robotic major hepatectomy (R-MH) and laparoscopic major hepatectomy (L-MH). Background: Robotic techniques may overcome the limitations of laparoscopic liver resection. However, it is unknown whether R-MH is superior to L-MH. Methods: This is a post hoc analysis of a multicenter database of patients undergoing R-MH or L-MH at 59 international centers from 2008 to 2021. Data on patient demographics, center experience volume, perioperative outcomes, and tumor characteristics were collected and analyzed. Both 1:1 propensity-score matched (PSM) and coarsened-exact matched (CEM) analyses were performed to minimize selection bias between both groups Results: A total of 4822 cases met the study criteria, of which 892 underwent R-MH and 3930 underwent L-MH. Both 1:1 PSM (841 R-MH vs. 841 L-MH) and CEM (237 R-MH vs. 356 L-MH) were performed. R-MH was associated with significantly less blood loss {PSM:200.0 [interquartile range (IQR):100.0, 450.0] vs 300.0 (IQR:150.0, 500.0) mL; P = 0.012; CEM:170.0 (IQR: 90.0, 400.0) vs 200.0 (IQR:100.0, 400.0) mL; P = 0.006}, lower rates of Pringle maneuver application (PSM: 47.1% vs 63.0%; P < 0.001; CEM: 54.0% vs 65.0%; P = 0.007) and open conversion (PSM: 5.1% vs 11.9%; P < 0.001; CEM: 5.5% vs 10.4%, P = 0.04) compared with L-MH. On subset analysis of 1273 patients with cirrhosis, R-MH was associated with a lower postoperative morbidity rate (PSM: 19.5% vs 29.9%; P = 0.02; CEM 10.4% vs 25.5%; P = 0.02) and shorter postoperative stay [PSM: 6.9 (IQR: 5.0, 9.0) days vs 8.0 (IQR: 6.0 11.3) days; P < 0.001; CEM 7.0 (IQR: 5.0, 9.0) days vs 7.0 (IQR: 6.0, 10.0) days; P = 0.047]. Conclusions: This international multicenter study demonstrated that R-MH was comparable to L-MH in safety and was associated with reduced blood loss, lower rates of Pringle maneuver application, and conversion to open surgery.

本文言語	英語
ページ（範囲）	969-975
ページ数	7
ジャーナル	Annals of Surgery
巻	278
号	6
DOI	https://doi.org/10.1097/SLA.0000000000005855
出版ステータス	出版済み - 01-12-2023

All Science Journal Classification (ASJC) codes

外科

文献へのアクセス

10.1097/SLA.0000000000005855

他のファイルとリンク

フィンガープリント

「Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Liu, Q., Zhang, W., Zhao, J. J., Syn, N. L., Cipriani, F., Alzoubi, M., Aghayan, D. L., Siow, T. F., Lim, C., Scatton, O., Herman, P., Coelho, F. F., Marino, M. V., Mazzaferro, V., Chiow, A. K. H., Sucandy, I., Ivanecz, A., Choi, S. H., Lee, J. H., ... Goh, B. K. P. (2023). Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases. Annals of Surgery, 278(6), 969-975. https://doi.org/10.1097/SLA.0000000000005855

@article{0d93b2bfab1744b3829a1a50fcb6a4f1,

title = "Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases",

abstract = "Objective: To compare the outcomes between robotic major hepatectomy (R-MH) and laparoscopic major hepatectomy (L-MH). Background: Robotic techniques may overcome the limitations of laparoscopic liver resection. However, it is unknown whether R-MH is superior to L-MH. Methods: This is a post hoc analysis of a multicenter database of patients undergoing R-MH or L-MH at 59 international centers from 2008 to 2021. Data on patient demographics, center experience volume, perioperative outcomes, and tumor characteristics were collected and analyzed. Both 1:1 propensity-score matched (PSM) and coarsened-exact matched (CEM) analyses were performed to minimize selection bias between both groups Results: A total of 4822 cases met the study criteria, of which 892 underwent R-MH and 3930 underwent L-MH. Both 1:1 PSM (841 R-MH vs. 841 L-MH) and CEM (237 R-MH vs. 356 L-MH) were performed. R-MH was associated with significantly less blood loss {PSM:200.0 [interquartile range (IQR):100.0, 450.0] vs 300.0 (IQR:150.0, 500.0) mL; P = 0.012; CEM:170.0 (IQR: 90.0, 400.0) vs 200.0 (IQR:100.0, 400.0) mL; P = 0.006}, lower rates of Pringle maneuver application (PSM: 47.1% vs 63.0%; P < 0.001; CEM: 54.0% vs 65.0%; P = 0.007) and open conversion (PSM: 5.1% vs 11.9%; P < 0.001; CEM: 5.5% vs 10.4%, P = 0.04) compared with L-MH. On subset analysis of 1273 patients with cirrhosis, R-MH was associated with a lower postoperative morbidity rate (PSM: 19.5% vs 29.9%; P = 0.02; CEM 10.4% vs 25.5%; P = 0.02) and shorter postoperative stay [PSM: 6.9 (IQR: 5.0, 9.0) days vs 8.0 (IQR: 6.0 11.3) days; P < 0.001; CEM 7.0 (IQR: 5.0, 9.0) days vs 7.0 (IQR: 6.0, 10.0) days; P = 0.047]. Conclusions: This international multicenter study demonstrated that R-MH was comparable to L-MH in safety and was associated with reduced blood loss, lower rates of Pringle maneuver application, and conversion to open surgery.",

keywords = "extended right hepatectomy, laparoscopic liver resection, major hepatectomy, right hepatectomy, robotic liver resection",

author = "Qu Liu and Wanguang Zhang and Zhao, {Joseph J.} and Syn, {Nicholas L.} and Federica Cipriani and Mohammad Alzoubi and Aghayan, {Davit L.} and Siow, {Tiing Foong} and Chetana Lim and Olivier Scatton and Paulo Herman and Coelho, {Fabricio Ferreira} and Marino, {Marco V.} and Vincenzo Mazzaferro and Chiow, {Adrian K.H.} and Iswanto Sucandy and Arpad Ivanecz and Choi, {Sung Hoon} and Lee, {Jae Hoon} and Mikel Prieto and Marco Vivarelli and Felice Giuliante and {Dalla Valle}, Bernardo and Andrea Ruzzenente and Yong, {Chee Chien} and Zewei Chen and Mengqiu Yin and Constantino Fondevila and Mikhail Efanov and Zenichi Morise and {Di Benedetto}, Fabrizio and Raffaele Brustia and {Dalla Valle}, Raffaele and Ugo Boggi and David Geller and Andrea Belli and Riccardo Memeo and Salvatore Gruttadauria and Alejandro Mejia and Park, {James O.} and Fernando Rotellar and Choi, {Gi Hong} and Ricardo Robles-Campos and Xiaoying Wang and Sutcliffe, {Robert P.} and Moritz Schmelzle and Johann Pratschke and Tang, {Chung Ngai} and Chong, {Charing C.N.} and Lee, {Kit Fai} and Juul Meurs and Mathieu D'Hondt and Kazuteru Monden and Santiago Lopez-Ben and Kingham, {Thomas Peter} and Alessandro Ferrero and Ettorre, {Giuseppe Maria} and {Levi Sandri}, {Giovanni Battista} and Mansour Saleh and Daniel Cherqui and Junhao Zheng and Xiao Liang and Alessandro Mazzotta and Olivier Soubrane and Go Wakabayashi and Troisi, {Roberto I.} and Cheung, {Tan To} and Yutaro Kato and Atsushi Sugioka and Mizelle D'Silva and Han, {Ho Seong} and Nghia, {Phan Phuoc} and Long, {Tran Cong Duy} and Bj{\o}rn Edwin and David Fuks and Chen, {Kuo Hsin} and {Abu Hilal}, Mohammad and Luca Aldrighetti and Rong Liu and Goh, {Brian K.P.}",

year = "2023",

month = dec,

day = "1",

doi = "10.1097/SLA.0000000000005855",

language = "English",

volume = "278",

pages = "969--975",

journal = "Annals of Surgery",

issn = "0003-4932",

publisher = "Wolters Kluwer Health",

number = "6",

}

Liu, Q, Zhang, W, Zhao, JJ, Syn, NL, Cipriani, F, Alzoubi, M, Aghayan, DL, Siow, TF, Lim, C, Scatton, O, Herman, P, Coelho, FF, Marino, MV, Mazzaferro, V, Chiow, AKH, Sucandy, I, Ivanecz, A, Choi, SH, Lee, JH, Prieto, M, Vivarelli, M, Giuliante, F, Dalla Valle, B, Ruzzenente, A, Yong, CC, Chen, Z, Yin, M, Fondevila, C, Efanov, M, Morise, Z, Di Benedetto, F, Brustia, R, Dalla Valle, R, Boggi, U, Geller, D, Belli, A, Memeo, R, Gruttadauria, S, Mejia, A, Park, JO, Rotellar, F, Choi, GH, Robles-Campos, R, Wang, X, Sutcliffe, RP, Schmelzle, M, Pratschke, J, Tang, CN, Chong, CCN, Lee, KF, Meurs, J, D'Hondt, M, Monden, K, Lopez-Ben, S, Kingham, TP, Ferrero, A, Ettorre, GM, Levi Sandri, GB, Saleh, M, Cherqui, D, Zheng, J, Liang, X, Mazzotta, A, Soubrane, O, Wakabayashi, G, Troisi, RI, Cheung, TT, Kato, Y , Sugioka, A, D'Silva, M, Han, HS, Nghia, PP, Long, TCD, Edwin, B, Fuks, D, Chen, KH, Abu Hilal, M, Aldrighetti, L, Liu, R & Goh, BKP 2023, 'Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases', Annals of Surgery, vol. 278, no. 6, pp. 969-975. https://doi.org/10.1097/SLA.0000000000005855

TY - JOUR

T1 - Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies

T2 - An International Multicenter Study of 4822 Cases

AU - Liu, Qu

AU - Zhang, Wanguang

AU - Zhao, Joseph J.

AU - Syn, Nicholas L.

AU - Cipriani, Federica

AU - Alzoubi, Mohammad

AU - Aghayan, Davit L.

AU - Siow, Tiing Foong

AU - Lim, Chetana

AU - Scatton, Olivier

AU - Herman, Paulo

AU - Coelho, Fabricio Ferreira

AU - Marino, Marco V.

AU - Mazzaferro, Vincenzo

AU - Chiow, Adrian K.H.

AU - Sucandy, Iswanto

AU - Ivanecz, Arpad

AU - Choi, Sung Hoon

AU - Lee, Jae Hoon

AU - Prieto, Mikel

AU - Vivarelli, Marco

AU - Giuliante, Felice

AU - Dalla Valle, Bernardo

AU - Ruzzenente, Andrea

AU - Yong, Chee Chien

AU - Chen, Zewei

AU - Yin, Mengqiu

AU - Fondevila, Constantino

AU - Efanov, Mikhail

AU - Morise, Zenichi

AU - Di Benedetto, Fabrizio

AU - Brustia, Raffaele

AU - Dalla Valle, Raffaele

AU - Boggi, Ugo

AU - Geller, David

AU - Belli, Andrea

AU - Memeo, Riccardo

AU - Gruttadauria, Salvatore

AU - Mejia, Alejandro

AU - Park, James O.

AU - Rotellar, Fernando

AU - Choi, Gi Hong

AU - Robles-Campos, Ricardo

AU - Wang, Xiaoying

AU - Sutcliffe, Robert P.

AU - Schmelzle, Moritz

AU - Pratschke, Johann

AU - Tang, Chung Ngai

AU - Chong, Charing C.N.

AU - Lee, Kit Fai

AU - Meurs, Juul

AU - D'Hondt, Mathieu

AU - Monden, Kazuteru

AU - Lopez-Ben, Santiago

AU - Kingham, Thomas Peter

AU - Ferrero, Alessandro

AU - Ettorre, Giuseppe Maria

AU - Levi Sandri, Giovanni Battista

AU - Saleh, Mansour

AU - Cherqui, Daniel

AU - Zheng, Junhao

AU - Liang, Xiao

AU - Mazzotta, Alessandro

AU - Soubrane, Olivier

AU - Wakabayashi, Go

AU - Troisi, Roberto I.

AU - Cheung, Tan To

AU - Kato, Yutaro

AU - Sugioka, Atsushi

AU - D'Silva, Mizelle

AU - Han, Ho Seong

AU - Nghia, Phan Phuoc

AU - Long, Tran Cong Duy

AU - Edwin, Bjørn

AU - Fuks, David

AU - Chen, Kuo Hsin

AU - Abu Hilal, Mohammad

AU - Aldrighetti, Luca

AU - Liu, Rong

AU - Goh, Brian K.P.

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Objective: To compare the outcomes between robotic major hepatectomy (R-MH) and laparoscopic major hepatectomy (L-MH). Background: Robotic techniques may overcome the limitations of laparoscopic liver resection. However, it is unknown whether R-MH is superior to L-MH. Methods: This is a post hoc analysis of a multicenter database of patients undergoing R-MH or L-MH at 59 international centers from 2008 to 2021. Data on patient demographics, center experience volume, perioperative outcomes, and tumor characteristics were collected and analyzed. Both 1:1 propensity-score matched (PSM) and coarsened-exact matched (CEM) analyses were performed to minimize selection bias between both groups Results: A total of 4822 cases met the study criteria, of which 892 underwent R-MH and 3930 underwent L-MH. Both 1:1 PSM (841 R-MH vs. 841 L-MH) and CEM (237 R-MH vs. 356 L-MH) were performed. R-MH was associated with significantly less blood loss {PSM:200.0 [interquartile range (IQR):100.0, 450.0] vs 300.0 (IQR:150.0, 500.0) mL; P = 0.012; CEM:170.0 (IQR: 90.0, 400.0) vs 200.0 (IQR:100.0, 400.0) mL; P = 0.006}, lower rates of Pringle maneuver application (PSM: 47.1% vs 63.0%; P < 0.001; CEM: 54.0% vs 65.0%; P = 0.007) and open conversion (PSM: 5.1% vs 11.9%; P < 0.001; CEM: 5.5% vs 10.4%, P = 0.04) compared with L-MH. On subset analysis of 1273 patients with cirrhosis, R-MH was associated with a lower postoperative morbidity rate (PSM: 19.5% vs 29.9%; P = 0.02; CEM 10.4% vs 25.5%; P = 0.02) and shorter postoperative stay [PSM: 6.9 (IQR: 5.0, 9.0) days vs 8.0 (IQR: 6.0 11.3) days; P < 0.001; CEM 7.0 (IQR: 5.0, 9.0) days vs 7.0 (IQR: 6.0, 10.0) days; P = 0.047]. Conclusions: This international multicenter study demonstrated that R-MH was comparable to L-MH in safety and was associated with reduced blood loss, lower rates of Pringle maneuver application, and conversion to open surgery.

AB - Objective: To compare the outcomes between robotic major hepatectomy (R-MH) and laparoscopic major hepatectomy (L-MH). Background: Robotic techniques may overcome the limitations of laparoscopic liver resection. However, it is unknown whether R-MH is superior to L-MH. Methods: This is a post hoc analysis of a multicenter database of patients undergoing R-MH or L-MH at 59 international centers from 2008 to 2021. Data on patient demographics, center experience volume, perioperative outcomes, and tumor characteristics were collected and analyzed. Both 1:1 propensity-score matched (PSM) and coarsened-exact matched (CEM) analyses were performed to minimize selection bias between both groups Results: A total of 4822 cases met the study criteria, of which 892 underwent R-MH and 3930 underwent L-MH. Both 1:1 PSM (841 R-MH vs. 841 L-MH) and CEM (237 R-MH vs. 356 L-MH) were performed. R-MH was associated with significantly less blood loss {PSM:200.0 [interquartile range (IQR):100.0, 450.0] vs 300.0 (IQR:150.0, 500.0) mL; P = 0.012; CEM:170.0 (IQR: 90.0, 400.0) vs 200.0 (IQR:100.0, 400.0) mL; P = 0.006}, lower rates of Pringle maneuver application (PSM: 47.1% vs 63.0%; P < 0.001; CEM: 54.0% vs 65.0%; P = 0.007) and open conversion (PSM: 5.1% vs 11.9%; P < 0.001; CEM: 5.5% vs 10.4%, P = 0.04) compared with L-MH. On subset analysis of 1273 patients with cirrhosis, R-MH was associated with a lower postoperative morbidity rate (PSM: 19.5% vs 29.9%; P = 0.02; CEM 10.4% vs 25.5%; P = 0.02) and shorter postoperative stay [PSM: 6.9 (IQR: 5.0, 9.0) days vs 8.0 (IQR: 6.0 11.3) days; P < 0.001; CEM 7.0 (IQR: 5.0, 9.0) days vs 7.0 (IQR: 6.0, 10.0) days; P = 0.047]. Conclusions: This international multicenter study demonstrated that R-MH was comparable to L-MH in safety and was associated with reduced blood loss, lower rates of Pringle maneuver application, and conversion to open surgery.

KW - extended right hepatectomy

KW - laparoscopic liver resection

KW - major hepatectomy

KW - right hepatectomy

KW - robotic liver resection

UR - http://www.scopus.com/inward/record.url?scp=85153586937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85153586937&partnerID=8YFLogxK

U2 - 10.1097/SLA.0000000000005855

DO - 10.1097/SLA.0000000000005855

M3 - Article

C2 - 37058429

AN - SCOPUS:85153586937

SN - 0003-4932

VL - 278

SP - 969

EP - 975

JO - Annals of Surgery

JF - Annals of Surgery

IS - 6

ER -