Proposal for novel histological findings of colorectal liver metastases with preoperative chemotherapy

Kazuyuki Ishida, Noriyuki Uesugi, Yasushi Hasegawa, Ryo Sugimoto, Takeshi Takahara, Koki Otsuka, Hiroyuki Nitta, Tomonori Kawasaki, Go Wakabayashi, Tamotsu Sugai

研究成果: Article査読

4 被引用数 (Scopus)

抄録

This study aimed to clarify the histological characteristics related to preoperative chemotherapy for colorectal liver metastases (CRLM). Sixty-three patients with CRLM were divided into two groups: CRLM with chemotherapy (41 cases, group A) and CRLM without chemotherapy (22 cases; surgical treatment alone, group S) to identify the histological differences associated with chemotherapy. In addition, we investigated the effects of combination chemotherapy on the histology of metastatic lesions. Infarct-like necrosis (ILN), three-zonal changes, and cholesterol clefts were more frequent in group A than in group S (P < 0.05). ILN and three-zonal changes were more common in the 5-FU with leucovorin and oxaliplatin (FOLFOX), or 5-FU with leucovorin and irinotecan (FOLFIRI) with or without additional bevacizumab groups than in group S (P < 0.05). Cholesterol clefts in the FOLFOX or FOLFIRI with bevacizumab group and foamy macrophages in the FOLFOX or FOLFIRI group were more common than in group S (P < 0.05). Cases with more than three of the four histological findings-i.e. ILN, three-zonal changes, cholesterol clefts, and foamy macrophages-were more frequent in the FOLFOX or FOLFIRI with or without additional bevacizumab groups than in group S (P < 0.05). We showed histological findings for every representative chemotherapy regimen for CRLM to clarify the effects of preoperative chemotherapy.

本文言語English
ページ(範囲)367-373
ページ数7
ジャーナルPathology International
65
7
DOI
出版ステータスPublished - 01-07-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

フィンガープリント

「Proposal for novel histological findings of colorectal liver metastases with preoperative chemotherapy」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル