Prostaglandin E receptor EP1 controls impulsive behavior under stress

Yoko Matsuoka, Tomoyuki Furuyashiki, Kiyofumi Yamada, Taku Nagai, Haruhiko Bito, Yasuhiro Tanaka, Shiho Kitaoka, Fumitaka Ushikubi, Toshitaka Nabeshima, Shuh Narumiya

研究成果: Article

74 引用 (Scopus)

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Animals under stress take adaptive actions that may lead to various types of behavioral disinhibition. Such behavioral disinhibition, when expressed excessively and impulsively, can result in harm in individuals and cause a problem in our society. We now show that, under social or environmental stress, mice deficient in prostaglandin E receptor subtype EP1 (Ptger1-/-) manifest behavioral disinhibition, including impulsive aggression with defective social interaction, impaired cliff avoidance, and an exaggerated acoustic startle response. This phenotype was reproduced in wild-type mice by administration of an EP1-selective antagonist, whereas administration of an EP1-selective agonist suppressed electric-shock-induced impulsive aggression. Dopamine turnover in the frontal cortex and striatum was increased in Ptger1-/- mice, and administration of dopaminergic antagonists corrected their behavioral phenotype. These results suggest that prostaglandin E2 acts through EP1 to control impulsive behavior under stress, a finding potentially exploitable for development of drugs that attenuate impulsive behavior in humans.

元の言語English
ページ(範囲)16066-16071
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
102
発行部数44
DOI
出版物ステータスPublished - 01-11-2005
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • General

これを引用

Matsuoka, Y., Furuyashiki, T., Yamada, K., Nagai, T., Bito, H., Tanaka, Y., Kitaoka, S., Ushikubi, F., Nabeshima, T., & Narumiya, S. (2005). Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proceedings of the National Academy of Sciences of the United States of America, 102(44), 16066-16071. https://doi.org/10.1073/pnas.0504908102