Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

研究成果: Conference contribution

4 引用 (Scopus)

抜粋

Abnormal intracellular signaling molecules in dopamine signal transduction are thought to be associated with the pathophysiology of methamphetamine (METH)-use disorder. A recent study reported that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in dopamine 2 receptor signaling. We therefore analyzed the association between the Par-4 gene (PAWR) and METH-use disorder in a Japanese population (191 patients with METH-use disorder and 466 healthy controls). Using the recommended "gene-based" association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant allele/genotype-wise or haplotype-wise association was found between PAWR and METH-use disorder. These results suggest that PAWR does not play a major role in METH-use disorders in the Japanese population.

元の言語English
ホスト出版物のタイトルDrug Addiction
ホスト出版物のサブタイトルResearch Frontiers and Treatment Advances
出版者Blackwell Publishing Inc.
ページ83-88
ページ数6
ISBN(印刷物)9781573317184
DOI
出版物ステータスPublished - 10-2008

出版物シリーズ

名前Annals of the New York Academy of Sciences
1139
ISSN(印刷物)0077-8923
ISSN(電子版)1749-6632

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

これを引用

Kishi, T., Ikeda, M., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Inada, T., Harano, M., Komiyama, T., Hori, T., Yamada, M., Iyo, M., Sora, I., Sekine, Y., Ozaki, N., Ujike, H., & Iwata, N. (2008). Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Jpanese population. : Drug Addiction: Research Frontiers and Treatment Advances (pp. 83-88). (Annals of the New York Academy of Sciences; 巻数 1139). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1432.024