Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3: A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study)

Kazuya Mikami, Kotaro Ozasa, Masahiro Nakao, Tsuneharu Miki, Kyohei Hayashi, Yoshiyuki Watanabe, Mitsuru Mori, Fumio Sakauchi, Masakazu Washio, Tatsuhiko Kubo, Koji Suzuki, Kenji Wakai, Kei Nakachi, Kazuo Tajima, Yoshinori Ito, Yutaka Inaba, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka MotohashiIchiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Koji Tamakoshi, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

研究成果: Article

13 引用 (Scopus)

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High levels of insulin-like growth factor (IGF)-I are reported to be associated with an increased risk of prostate cancer. On the other hand, the insulin-like growth factor binding protein-3 (IGFBP-3) may decrease the risk. We therefore investigated the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a casecontrol study nested within a large-scale cohort in Japan (the Japan Collaborative Cohort Study). Information on lifestyles and sera of the subjects were collected in 1988-90. Serum IGF-I, IGF-II and IGFBP-3 were measured in sera stored at -80oC by immuno-radiometric assay. In 13,508 male subjects of the cohort who donated sera, 40 cases and 120 controls (1:3 matched with age and survey area) were identified. Ages of the cases ranged from 59 to 79 years, with a mean of 69.8. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the highest and middle tertiles compared with the lowest in controls using a conditional logistic model. Nonadjusted ORs for the highest tertiles were 0.99 (95% CI, 0.34-2.91) for IGF-I (trend-P = 0.60), 1.91 (95% CI, 0.68-5.38) for IGFBP-3 (trend-P = 0.23), 1.73 (95% CI, 0.69-3.47) for IGF-II (trend-P = 0.23), and 0.67 (95% CI, 0.26-1.76) for the IGF-I/IGBP-3 ratio (trend-P = 0.83). Serum levels of IGF-I, IGF-II, IGFBP-3, or IGF-I/IGFBP-3 ratio were thus not thought to be associated with risk of prostate cancer.

元の言語English
ページ(範囲)57-62
ページ数6
ジャーナルAsian Pacific Journal of Cancer Prevention
10
発行部数SUPPL.1
出版物ステータスPublished - 05-12-2009

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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    Mikami, K., Ozasa, K., Nakao, M., Miki, T., Hayashi, K., Watanabe, Y., Mori, M., Sakauchi, F., Washio, M., Kubo, T., Suzuki, K., Wakai, K., Nakachi, K., Tajima, K., Ito, Y., Inaba, Y., Tamakoshi, A., Mori, M., Sakauchi, F., ... Shio, H. (2009). Prostate Cancer Risk in Relation to Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3: A Nested Case-Control Study in Large Scale Cohort Study in Japan (JACC Study). Asian Pacific Journal of Cancer Prevention, 10(SUPPL.1), 57-62.