Prostatic bleeding after prostatic biopsy effects oncological outcomes with laparoscopic radical prostatectomy

Tomoaki Takai, Teruo Inamoto, Kazumasa Komura, Takuya Tsujino, Tomohisa Matsunaga, Yuki Yoshikawa, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Hirofumi Uehara, Naokazu Ibuki, Kiyoshi Takahara, Hayahito Nomi, Satoshi Kiyama, Hayahito Azuma

研究成果: Article

抜粋

Background: We vigorously reviewed patients' operation record who had adhesion of the Denonvilliers' fascia and found out most of these patients had prostatic bleeding after prostatic gland biopsies. We examined the magnitude of prostatic bleeding and frequency after biopsies and the relationship with oncological outcomes. Materials and Methods: A total of 285 patients were selected for the final analyses. Inclusion criteria were as follows: Receiving MRI three weeks after biopsiesand laparoscopic radical prostatectomy within 300 days after biopsy. We divided the patients into two groups with (group A) or without (group B) prostatic bleeding. We examined the magnitude of prostatic bleeding after biopsies and the relationship with operation time (OT), positive surgical margin (PSM), biochemical recurrence (BCR) and other factors. Furthermore, we created a logistic-regression model to derive a propensity score for prostatic bleeding after biopsies, which included all patient and hospital characteristics as well as selected interaction terms, and we examined the relationship with PSM and BCR. Results: In all patients, the OT in the group B was shorter than the group A (p < 0.001). Prostatic bleeding was associated with PSM (p=0.000) and BCR (p=0.036). In this propensity-matched cohort, 11 of 116 patients in the group B had PSM as compared with 36 of 116 patients from group A (match-adjusted odds ratio, 4.30; 95%CI confidence interval, 2.06 to 8.96; P=0.000). In addition, eight of 116 patients in group B encountered BCR, as compared with 18 of 116 patients in group A (match-adjusted odds ratio, 2.48; 95%CI, 1.03 to 5.96; P=0.042). Kaplan-Meier analysis in the propensity matching cohort showed a significant biochemical recurrence-free survival advantage for being free of prostate bleeding after biopsies. Conclusions: Our findings in the present cohort should help equip surgeons to pay attention to careful excision especially for those who experienced deferred prostatic bleeding.

元の言語English
ページ(範囲)1373-1377
ページ数5
ジャーナルAsian Pacific Journal of Cancer Prevention
17
発行部数3
DOI
出版物ステータスPublished - 19-04-2016

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All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

これを引用

Takai, T., Inamoto, T., Komura, K., Tsujino, T., Matsunaga, T., Yoshikawa, Y., Uchimoto, T., Saito, K., Tanda, N., Minami, K., Uehara, H., Ibuki, N., Takahara, K., Nomi, H., Kiyama, S., & Azuma, H. (2016). Prostatic bleeding after prostatic biopsy effects oncological outcomes with laparoscopic radical prostatectomy. Asian Pacific Journal of Cancer Prevention, 17(3), 1373-1377. https://doi.org/10.7314/APJCP.2016.17.3.1373