抄録
The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single preadministration (50 mg/kg). The repeated BPEE preadministration attenuated WIRS-induced gastric mucosal lesions and gastric mucosal oxidative stress more largely than the single BPEE preadministration. In addition, the repeated BPEE preadministration attenuated neutrophil infiltration in the gastric mucosa of rats exposed to WIRS. The protective effect of the repeated preadministration of BPEE against WIRS-induced gastric mucosal lesions was similar to that of a single preadministration of vitamin E (250 mg/kg) in terms of the extent and manner of protection. From these findings, it is concluded that BPEE preadministered in a repeated manner protects against gastric mucosal lesions in rats exposed to WIRS more effectively than BPEE preadministered in a single manner possibly through its antioxidant and anti-inflammatory actions.
| 元の言語 | English |
|---|---|
| 記事番号 | 383482 |
| ジャーナル | Evidence-based Complementary and Alternative Medicine |
| 巻 | 2014 |
| DOI | |
| 出版物ステータス | Published - 05-03-2014 |
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All Science Journal Classification (ASJC) codes
- Complementary and alternative medicine
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Protective effect of repeatedly preadministered brazilian propolis ethanol extract against stress-induced gastric mucosal lesions in rats. / Nakamura, Tadashi; Ohta, Yoshiji; Ikeno, Kumiko; Ohashi, Koji; Ikeno, Takeyuki.
：: Evidence-based Complementary and Alternative Medicine, 巻 2014, 383482, 05.03.2014.研究成果: Article
TY - JOUR
T1 - Protective effect of repeatedly preadministered brazilian propolis ethanol extract against stress-induced gastric mucosal lesions in rats
AU - Nakamura, Tadashi
AU - Ohta, Yoshiji
AU - Ikeno, Kumiko
AU - Ohashi, Koji
AU - Ikeno, Takeyuki
PY - 2014/3/5
Y1 - 2014/3/5
N2 - The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single preadministration (50 mg/kg). The repeated BPEE preadministration attenuated WIRS-induced gastric mucosal lesions and gastric mucosal oxidative stress more largely than the single BPEE preadministration. In addition, the repeated BPEE preadministration attenuated neutrophil infiltration in the gastric mucosa of rats exposed to WIRS. The protective effect of the repeated preadministration of BPEE against WIRS-induced gastric mucosal lesions was similar to that of a single preadministration of vitamin E (250 mg/kg) in terms of the extent and manner of protection. From these findings, it is concluded that BPEE preadministered in a repeated manner protects against gastric mucosal lesions in rats exposed to WIRS more effectively than BPEE preadministered in a single manner possibly through its antioxidant and anti-inflammatory actions.
AB - The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single preadministration (50 mg/kg). The repeated BPEE preadministration attenuated WIRS-induced gastric mucosal lesions and gastric mucosal oxidative stress more largely than the single BPEE preadministration. In addition, the repeated BPEE preadministration attenuated neutrophil infiltration in the gastric mucosa of rats exposed to WIRS. The protective effect of the repeated preadministration of BPEE against WIRS-induced gastric mucosal lesions was similar to that of a single preadministration of vitamin E (250 mg/kg) in terms of the extent and manner of protection. From these findings, it is concluded that BPEE preadministered in a repeated manner protects against gastric mucosal lesions in rats exposed to WIRS more effectively than BPEE preadministered in a single manner possibly through its antioxidant and anti-inflammatory actions.
UR - http://www.scopus.com/inward/record.url?scp=84896865864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896865864&partnerID=8YFLogxK
U2 - 10.1155/2014/383482
DO - 10.1155/2014/383482
M3 - Article
AN - SCOPUS:84896865864
VL - 2014
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
SN - 1741-427X
M1 - 383482
ER -