TY - JOUR
T1 - Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma
AU - Miyata, Kenji
AU - Hori, Toshinori
AU - Shimomura, Yasuto
AU - Joko, Masahiro
AU - Takayasu, Masakazu
AU - Okumura, Akihisa
N1 - Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Clinical case: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings. Conclusion: This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.
AB - Clinical case: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings. Conclusion: This case highlights the efficacy and tolerability of bevacizumab for the treatment of pseudoprogression in children with spinal low-grade gliomas.
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U2 - 10.1007/s00381-018-3841-7
DO - 10.1007/s00381-018-3841-7
M3 - Article
C2 - 29804214
AN - SCOPUS:85047422995
SN - 0256-7040
VL - 34
SP - 2305
EP - 2308
JO - Child's Nervous System
JF - Child's Nervous System
IS - 11
ER -