抄録
Recent molecular studies have revealed that the GM-CSF/RAS signaling pathway plays a central role in the pathogenesis of juvenile myelomonocytic leukemia (JMML). CFU-GM colony assay is an important test for GM-CSF hypersensitivity in patients with JMML, but requires specific skills. We established a simple and easy quantification method to test GM-CSF hypersensitivity, using a 3H-thymidine assay. With this quantification method, JMML patients with RAS mutations showed significantly higher GM-CSF sensitivity than JMML patients with PTPN11 mutations. This method will be useful not only in the diagnosis of JMML, but also to evaluate the difference of GM-CSF sensitivity among patients.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1036-1042 |
ページ数 | 7 |
ジャーナル | Leukemia Research |
巻 | 32 |
号 | 7 |
DOI | |
出版ステータス | 出版済み - 07-2008 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 血液学
- 腫瘍学
- 癌研究