Quantitative analysis of first-pass contrast-enhanced myocardial perfusion multidetector CT using a patlak plot method and extraction fraction correction during adenosine stress

Takashi Ichihara, Richard T. George, Joao A.C. Lima, Albert C. Lardo

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

7 被引用数 (Scopus)

抄録

The purpose of this study was to develop a quantitative method for myocardial blood flow (MBF) measurement that can be used to derive accurate myocardial perfusion measurements from dynamic multidetector computed tomography (MDCT) images by using a compartment model for calculating the first-order transfer constant (K1) with correction for the capillary transit extraction fraction (E). Six canine models of left anterior descending (LAD) artery stenosis were prepared and underwent first-pass contrast-enhanced MDCT perfusion imaging during adenosine infusion (0.14-0.21 mg/kg/min). K1, which is the first-order transfer constant from left ventricular (LV) blood to myocardium, was measured using the Patlak plot method applied to time-density curve data of the LV blood pool and myocardium. The results were compared against microsphere MBF measurements, and the extraction fraction of contrast agent was calculated. K1 is related to the regional MBF as K 1=EF, E=(1-exp(-PS/F)), where PS is the permeability-surface area product and F is myocardial flow. Based on the above relationship, a look-up table from K1 to MBF can be generated and Patlak plot-derived K 1 values can be converted to the calculated MBF. The calculated MBF and microsphere MBF showed a strong linear association. The extraction fraction in dogs as a function of flow (F) was E=(1-exp(-(0.253F+0.7871)/F)). Regional MBF can be measured accurately using the Patlak plot method based on a compartment model and look-up table with extraction fraction correction from K1 to MBF.

本文言語英語
ホスト出版物のタイトル2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
ページ3849-3852
ページ数4
DOI
出版ステータス出版済み - 2009
イベント2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009 - Orlando, FL, 米国
継続期間: 25-10-200931-10-2009

出版物シリーズ

名前IEEE Nuclear Science Symposium Conference Record
ISSN(印刷版)1095-7863

会議

会議2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
国/地域米国
CityOrlando, FL
Period25-10-0931-10-09

All Science Journal Classification (ASJC) codes

  • 放射線
  • 核物理学および高エネルギー物理学
  • 放射線学、核医学およびイメージング

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