Quantitative analysis of first-pass contrast-enhanced myocardial perfusion MRI using a Patlak plot method and blood saturation correction

Takashi Ichihara, Masaki Ishida, Kakuya Kitagawa, Yasutaka Ichikawa, Takahiro Natsume, Noriyasu Yamaki, Hisato Maeda, Kan Takeda, Hajime Sakuma

研究成果: ジャーナルへの寄稿学術論文査読

49 被引用数 (Scopus)

抄録

The objectives of this study were to develop a method for quantifying myocardial K1 and blood flow (MBF) with minimal operator interaction by using a Patlak plot method and to compare the MBF obtained by perfusion MRI with that from coronary sinus blood flow in the resting state. A method that can correct for the nonlinearity of the blood time-signal intensity curve on perfusion MR images was developed. Myocardial perfusion MR images were acquired with a saturation-recovery balanced turbo field-echo sequence in 10 patients. Coronary sinus blood flow was determined by phase-contrast cine MRI, and the average MBF was calculated as coronary sinus blood flow divided by left ventricular (LV) mass obtained by cine MRI. Patlak plot analysis was performed using the saturation-corrected blood time-signal intensity curve as an input function and the regional myocardial time-signal intensity curve as an output function. The mean MBF obtained by perfusion MRI was 86 ± 25 ml/min/100 g, showing good agreement with MBF calculated from coronary sinus blood flow (89 ± 30 ml/min/100 g, r = 0.74). The mean coefficient of variation for measuring regional MBF in 16 LV myocardial segments was 0.11. The current method using Patlak plot permits quantification of MBF with operator interaction limited to tracing the LV wall contours, registration, and time delays.

本文言語英語
ページ(範囲)373-383
ページ数11
ジャーナルMagnetic Resonance in Medicine
62
2
DOI
出版ステータス出版済み - 08-2009

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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