Quantitative assessment with intracoronary ultrasound of the mechanisms of restenosis after percutaneous transluminal coronary angioplasty and directional coronary atherectomy

Carlo Di Mario, Robert Gil, Edoardo Camenzind, Yukio Ozaki, Clemens von Birgelen, Victor Umans, Peter de Jaegere, Pim J. de Feyter, Jos R.T.C. Roelandt, Patrick W. Serruys

研究成果: ジャーナルへの寄稿学術論文査読

139 被引用数 (Scopus)

抄録

The mechanisms of immediate and late changes after percutaneous transluminal coronary angioplasty (PTCA) and directional coronary atherectomy (DCA) were assessed by serial ultrasound imaging in 18 patients treated with PTCA and 16 treated with DCA before, immediately after, and 6 months after coronary interventions. A reduction in plaque area was the main operative mechanism of DCA, explaining 66% of lumen enlargement. In the PTCA group, the increase in lumen area was the result of a more balanced combination of plaque reduction (52% of lumen increase) and increase in total lumen area (48%); p < 0.05 versus DCA. In the PTCA group, this last mechanism was prevalent (p < 0.05) in the lesions showing wall fracture or dissection after treatment and in the lesions with a mixed or calcific composition. In the PTCA group, concentric lesions showed a greater plaque compression than eccentric lesions (p < 0.02). Plaque increase was responsible for 92% and 32% of the late lumen loss after DCA and after PTCA, respectively (p < 0.05). In PTCA patients, a chronic reduction in total vessel area was the main operative mechanism of lumen reduction (67%) and was prevalent in lesions with a mixed or calcific composition (p < 0.05).

本文言語英語
ページ(範囲)772-777
ページ数6
ジャーナルThe American Journal of Cardiology
75
12
DOI
出版ステータス出版済み - 15-04-1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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