Rapid exacerbation of lymphocytic infundibuloneurohypophysitis

Kimitaka Shibue, Toshihito Fujii, Hisanori Goto, Yui Yamashita, Yoshihisa Sugimura, Masahiro Tanji, Akihiro Yasoda, Nobuya Inagaki

研究成果: Article

抜粋

Rationale: Lymphocytic hypophysitis is a relatively rare autoimmune disease defined by lymphocytic infiltration to the pituitary. Its rarity and wide spectrum of clinical manifestations make clarification of the pathology difficult. Here, we describe a case we examined from the primary diagnosis to final discharge, showing the serial progression of lymphocytic infundibuloneurohypophysitis (LINH) to panhypopituitarism with extrapituitary inflammatory invasion in a short period, and responding favorably to high-dose glucocorticoid treatment. Patient concerns: Polyuria, General fatigue and Nausea/Vomiting. Diagnoses: Central diabetes insipidus (CDI), Lymphocytic infundibuloneurohypophysitis (LINH). Interventions: Desmopressin acetate, High-dose glucocorticoid (GC) treatment. Outcomes: He was prescribed desmopressin acetate and subsequently discharged. A month later, he revisited our hospital with general fatigue and nausea/vomiting. A screening test disclosed hypopituitarism with adrenal insufficiency. MRI revealed expanded contrast enhancement to the peripheral extrapituitary lesion. He received high-dose GC treatment and the affected lesion exhibited marked improvement on MRI, along with the recovery of the anterior pituitary function. Lessons: This case demonstrates the potential for classical LINH to develop into panhypopituitarsim. We consider this is the first documentation of approaching the cause of atypical LINH with progressive clinical course from the pathological viewpoint.

元の言語English
記事番号e6034
ジャーナルMedicine (United States)
96
発行部数9
DOI
出版物ステータスPublished - 01-03-2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)

フィンガープリント Rapid exacerbation of lymphocytic infundibuloneurohypophysitis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Shibue, K., Fujii, T., Goto, H., Yamashita, Y., Sugimura, Y., Tanji, M., Yasoda, A., & Inagaki, N. (2017). Rapid exacerbation of lymphocytic infundibuloneurohypophysitis. Medicine (United States), 96(9), [e6034]. https://doi.org/10.1097/MD.0000000000006034