Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices

Miaomiao Sun; Toshihiro Kasama; Noritada Kaji; Shin Ichi Akiyama; Yukio Yuzawa; Seiichi Matsuo; Manabu Tokeshi; Yoshinobu Baba

Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices

Miaomiao Sun
, Toshihiro Kasama
, Noritada Kaji
, Shin Ichi Akiyama
, Yukio Yuzawa
, Seiichi Matsuo
, Manabu Tokeshi
, Yoshinobu Baba

藤田医科大学

研究成果: 書籍/レポートタイプへの寄稿 › 会議への寄与

3 被引用数 (Scopus)

抄録

We have developed immuno-pillar devices for rapid and easy-to-use immunoassay, but to improve the speed of assay (5-10 min) and the detection sensitivity (nM-pM level) has still remained as major problems toward the clinical applications of immuno-pillar devices. We report here the second-generation immuno-pillar devices with faster assay within 2 min and pM-fM detection sensitivity. New devices enable us to apply them to the clinical trials for the detection of multiple biomarkers (monocyte chemotactic protein 1 (MCP-1), angiotensinogen (AGT), liver-type fatty acid binding protein (L-FABP)) of diabetic nephropathy in human urine without any pretreatments.

本文言語	英語
ホスト出版物のタイトル	Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
出版社	Chemical and Biological Microsystems Society
ページ	812-814
ページ数	3
ISBN（印刷版）	9780979806452
出版ステータス	出版済み - 2012
イベント	16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, 日本継続期間: 28-10-2012 → 01-11-2012

出版物シリーズ

名前	Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

その他

その他	16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
国/地域	日本
City	Okinawa
Period	28-10-12 → 01-11-12

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

SDG 3 すべての人に健康と福祉を

All Science Journal Classification (ASJC) codes

化学工学（その他）
バイオエンジニアリング

他のファイルとリンク

引用スタイル

Sun, M., Kasama, T., Kaji, N., Akiyama, S. I., Yuzawa, Y., Matsuo, S., Tokeshi, M., & Baba, Y. (2012). Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 812-814). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.

Sun, Miaomiao ; Kasama, Toshihiro ; Kaji, Noritada その他. / Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. pp. 812-814 (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).

@inproceedings{fe0d2aefe85b435fb5641f84562be9f9,

title = "Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices",

abstract = "We have developed immuno-pillar devices for rapid and easy-to-use immunoassay, but to improve the speed of assay (5-10 min) and the detection sensitivity (nM-pM level) has still remained as major problems toward the clinical applications of immuno-pillar devices. We report here the second-generation immuno-pillar devices with faster assay within 2 min and pM-fM detection sensitivity. New devices enable us to apply them to the clinical trials for the detection of multiple biomarkers (monocyte chemotactic protein 1 (MCP-1), angiotensinogen (AGT), liver-type fatty acid binding protein (L-FABP)) of diabetic nephropathy in human urine without any pretreatments.",

author = "Miaomiao Sun and Toshihiro Kasama and Noritada Kaji and Akiyama, \{Shin Ichi\} and Yukio Yuzawa and Seiichi Matsuo and Manabu Tokeshi and Yoshinobu Baba",

year = "2012",

language = "English",

isbn = "9780979806452",

series = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",

publisher = "Chemical and Biological Microsystems Society",

pages = "812--814",

booktitle = "Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012",

note = "16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 ; Conference date: 28-10-2012 Through 01-11-2012",

}

Sun, M, Kasama, T, Kaji, N, Akiyama, SI, Yuzawa, Y, Matsuo, S, Tokeshi, M & Baba, Y 2012, Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices. in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Chemical and Biological Microsystems Society, pp. 812-814, 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Okinawa, 日本, 28-10-12.

Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices. / Sun, Miaomiao; Kasama, Toshihiro; Kaji, Noritada その他.
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. p. 812-814 (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).

研究成果: 書籍/レポートタイプへの寄稿 › 会議への寄与

TY - GEN

T1 - Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices

AU - Sun, Miaomiao

AU - Kasama, Toshihiro

AU - Kaji, Noritada

AU - Akiyama, Shin Ichi

AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

AU - Tokeshi, Manabu

AU - Baba, Yoshinobu

PY - 2012

Y1 - 2012

N2 - We have developed immuno-pillar devices for rapid and easy-to-use immunoassay, but to improve the speed of assay (5-10 min) and the detection sensitivity (nM-pM level) has still remained as major problems toward the clinical applications of immuno-pillar devices. We report here the second-generation immuno-pillar devices with faster assay within 2 min and pM-fM detection sensitivity. New devices enable us to apply them to the clinical trials for the detection of multiple biomarkers (monocyte chemotactic protein 1 (MCP-1), angiotensinogen (AGT), liver-type fatty acid binding protein (L-FABP)) of diabetic nephropathy in human urine without any pretreatments.

AB - We have developed immuno-pillar devices for rapid and easy-to-use immunoassay, but to improve the speed of assay (5-10 min) and the detection sensitivity (nM-pM level) has still remained as major problems toward the clinical applications of immuno-pillar devices. We report here the second-generation immuno-pillar devices with faster assay within 2 min and pM-fM detection sensitivity. New devices enable us to apply them to the clinical trials for the detection of multiple biomarkers (monocyte chemotactic protein 1 (MCP-1), angiotensinogen (AGT), liver-type fatty acid binding protein (L-FABP)) of diabetic nephropathy in human urine without any pretreatments.

UR - https://www.scopus.com/pages/publications/84901796095

UR - https://www.scopus.com/pages/publications/84901796095#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:84901796095

SN - 9780979806452

T3 - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

SP - 812

EP - 814

BT - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

PB - Chemical and Biological Microsystems Society

T2 - 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Y2 - 28 October 2012 through 1 November 2012

ER -

Sun M, Kasama T, Kaji N, Akiyama SI, Yuzawa Y, Matsuo S その他. Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society. 2012. p. 812-814. (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).

Rapid urine-based clinical diagnosis of diabetic nephropathy with femto-molar sensitivity by immuno-pillar devices

抄録

出版物シリーズ

その他

UN SDG

All Science Journal Classification (ASJC) codes

他のファイルとリンク

フィンガープリント

引用スタイル