Reactivation of human herpesviruses 6 and 7 in Kawasaki disease

Yoshihiko Kawano, Jun ichi Kawada, Noriko Nagai, Yoshinori Ito

研究成果: ジャーナルへの寄稿学術論文査読

7 被引用数 (Scopus)

抄録

Objectives: Kawasaki disease (KD) is one of the most common childhood vasculitides. Some serological studies have suggested an etiological relationship between KD and human herpesvirus (HHV)-6 or HHV-7. However, primary or reactivated HHV-6 and -7 has not been fully investigated in patients with KD. Methods: Twenty-three patients with KD were prospectively enrolled in this study. Peripheral blood was collected in the acute and convalescence phases, and HHV-6 and -7 viral loads were measured by real-time PCR. Results: In the acute phase, HHV-6 and -7 DNA was detected in 7 (30%) patients each, compared to 13 (57%) and 9 (39%) patients in the convalescence phase, respectively. HHV-6 and -7 DNA loads were significantly higher in the convalescence phase than in the acute phase. Significant increases in HHV-6 and -7 DNA loads were not observed in disease control patients. Taking into account HHV-6 and -7 serostatus, reactivation of HHV-6 and -7 was observed in 7 and 9 patients, respectively. KD patients with HHV-6 reactivation showed higher C-reactive protein levels and more frequently required steroid therapies than patients without reactivation. Conclusion: HHV-6 and -7 reactivation is frequent in KD patients. HHV-6 reactivation might exacerbate the severity of KD.

本文言語英語
ページ(範囲)651-655
ページ数5
ジャーナルModern Rheumatology
29
4
DOI
出版ステータス出版済み - 04-07-2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学一般

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