Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Shirou Sakuma; Hideyuki Saya; Mitsuhiro Tada; Mitsuyoshi Nakao; Toshiyoshi Fujiwara; Jack A. Roth; Yutaka Sawamura; Yumiko Shinohe; Abe Hiroshi

doi:10.1016/S0014-5793(96)01234-3

Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Shirou Sakuma, Hideyuki Saya, Mitsuhiro Tada, Mitsuyoshi Nakao, Toshiyoshi Fujiwara, Jack A. Roth, Yutaka Sawamura, Yumiko Shinohe, Abe Hiroshi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

30 被引用数 (Scopus)

抄録

We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.

本文言語	英語
ページ（範囲）	165-169
ページ数	5
ジャーナル	FEBS Letters
巻	398
号	2-3
DOI	https://doi.org/10.1016/S0014-5793(96)01234-3
出版ステータス	出版済み - 02-12-1996
外部発表	はい

All Science Journal Classification (ASJC) codes

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/S0014-5793(96)01234-3

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title = "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein",

abstract = "We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.",

author = "Shirou Sakuma and Hideyuki Saya and Mitsuhiro Tada and Mitsuyoshi Nakao and Toshiyoshi Fujiwara and Roth, {Jack A.} and Yutaka Sawamura and Yumiko Shinohe and Abe Hiroshi",

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T1 - Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

AU - Sakuma, Shirou

AU - Saya, Hideyuki

AU - Tada, Mitsuhiro

AU - Nakao, Mitsuyoshi

AU - Fujiwara, Toshiyoshi

AU - Roth, Jack A.

AU - Sawamura, Yutaka

AU - Shinohe, Yumiko

AU - Hiroshi, Abe

PY - 1996/12/2

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AB - We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.

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Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

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