Receptor signaling integration by TRP channelsomes

Yasuo Mori, Taketoshi Kajimoto, Akito Nakao, Nobuaki Takahashi, Shigeki Kiyonaka

研究成果: Conference contribution

8 被引用数 (Scopus)

抄録

Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca 2+ across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form "channelsomes", most of which function as Ca 2+ signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.

本文言語English
ホスト出版物のタイトルTransient Receptor Potential Channels
編集者Shahidul Islam, Shahidul Islam
ページ373-389
ページ数17
DOI
出版ステータスPublished - 15-12-2011

出版物シリーズ

名前Advances in Experimental Medicine and Biology
704
ISSN(印刷版)0065-2598

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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