抄録
The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.
本文言語 | 英語 |
---|---|
ページ(範囲) | 253-259 |
ページ数 | 7 |
ジャーナル | Life Sciences |
巻 | 51 |
号 | 4 |
DOI | |
出版ステータス | 出版済み - 1992 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 薬理学、毒性学および薬学一般
- 生化学、遺伝学、分子生物学一般