Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase

Yohei Doi; David L. Paterson; Jennifer M. Adams-Haduch; Hanna E. Sidjabat; Alexandra O'Keefe; Andrea Endimiani; Robert A. Bonomo

doi:10.1128/AAC.00133-09

Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase

Yohei Doi, David L. Paterson, Jennifer M. Adams-Haduch, Hanna E. Sidjabat, Alexandra O'Keefe, Andrea Endimiani, Robert A. Bonomo

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

26 被引用数 (Scopus)

抄録

Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the bla_CMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

本文言語	英語
ページ（範囲）	3159-3161
ページ数	3
ジャーナル	Antimicrobial agents and chemotherapy
巻	53
号	7
DOI	https://doi.org/10.1128/AAC.00133-09
出版ステータス	出版済み - 07-2009
外部発表	はい

All Science Journal Classification (ASJC) codes

薬理学
薬理学（医学）
感染症

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1128/AAC.00133-09

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title = "Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase",

abstract = "Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.",

author = "Yohei Doi and Paterson, {David L.} and Adams-Haduch, {Jennifer M.} and Sidjabat, {Hanna E.} and Alexandra O'Keefe and Andrea Endimiani and Bonomo, {Robert A.}",

year = "2009",

month = jul,

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language = "English",

volume = "53",

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AU - Doi, Yohei

AU - Paterson, David L.

AU - Adams-Haduch, Jennifer M.

AU - Sidjabat, Hanna E.

AU - O'Keefe, Alexandra

AU - Endimiani, Andrea

AU - Bonomo, Robert A.

PY - 2009/7

Y1 - 2009/7

N2 - Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

AB - Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 7

ER -

Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase

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All Science Journal Classification (ASJC) codes

UN SDG

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