Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats

Kiyofumi Yamada, Yukihiro Noda, Yumiko Komori, Hisayoshi Sugihara, Takaaki Hasegawa, Toshitaka Nabeshima

研究成果: Article

70 引用 (Scopus)

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Nitric oxide (NO) plays an important role as a diffusible messenger in learning and memory. To determine whether changes in NO production in the brain may be involved in aging-associated brain dysfunction, we measured the performance of aged rats in a radial arm maze task, and carried out histochemical examination of the changes in NADPH diaphorase (NADPH-d)-containing neurons in the brains of aged rats. The performance of aged rats (30 months old) in a radial arm maze task was significantly impaired compared to the performance of young rats (3 months old). The number of neurons containing NADPH-d reactivity in the cerebral cortex and striatum of aged rats was significantly reduced, by approximately 50 and 30%, respectively, compared to that in young rats. NO synthase activity in discrete brain regions of aged rats, i.e., in the cerebral cortex, striatum and hippocampus was not different from that in young rats, although the activity in the cerebellum of aged rats was significantly lower than that in young rats. These results suggest that the reduction in the number of NADPH-d-positive cells in the brains of aged rats may be involved in aging-associated learning impairment in rats.

元の言語English
ページ(範囲)393-402
ページ数10
ジャーナルNeuroscience Research
24
発行部数4
DOI
出版物ステータスPublished - 03-1996
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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