Reduction of activity, but no decrease in concentration, of erythrocyte Cu,Zn-superoxide dismutase by hyperglycaemia in diabetic patients

M. Kotake, R. Shinohara, K. Kato, N. Hayakawa, R. Hayashi, K. Uchimura, M. Makino, M. Nagata, H. Kakizawa, H. Nakagawa, A. Nagasaka, M. Itoh

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Cu,Zn-superoxide dismutase (SOD) activity in erythrocytes is affected by various diseases, including diabetes mellitus (DM). We investigated changes in the Cu,Zn-SOD activity compared to changes in the Cu,ZN-SOD concentration in erythrocytes obtained from patients with Type 2 (non-insulin-dependent) diabetest mellitus. Cu,Zn-SOD activity in erythrocytes was significantly lower in Type 2 DM patients than in healthy non-diabetic subjects. The activity correlated negatively with HbA(1c), but not with other indicators of metabolic control, such as fasting blood glucose or plasma cholesterol or triglyceride. However, there was no statistically significant difference in erythrocyte concentration of Cu,Zn-SOD between diabetic and control samples. Concentration did not correlate with enzymatic activity or HbA(1c). These findings indicate that the inactivation of Cu,Zn-SOD activity in erythrocytes of Type 2 DM patients by hyperglycaemia may be slow, because there is a negative correlation between the enzyme activities and HbA(1c) levels, but not fasting blood glucose levels. This is consistent with glycosylation of the active site of Cu,Zn-SOD, without any effect of hyperglycaemia on the concentration of Cu,Zn-SOD.

本文言語English
ページ(範囲)668-671
ページ数4
ジャーナルDiabetic Medicine
15
8
DOI
出版ステータスPublished - 1998

All Science Journal Classification (ASJC) codes

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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