TY - JOUR
T1 - Reduction of severe acute respiratory syndrome coronavirus-2 infectivity by admissible concentration of ozone gas and water
AU - Murata, Takayuki
AU - Komoto, Satoshi
AU - Iwahori, Satoko
AU - Sasaki, Jun
AU - Nishitsuji, Hironori
AU - Hasebe, Terumitsu
AU - Hoshinaga, Kiyotaka
AU - Yuzawa, Yukio
N1 - Publisher Copyright:
© 2020 The Societies and John Wiley & Sons Australia, Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the global coronavirus disease 2019 (COVID-19) pandemic. Because complete elimination of SARS-CoV-2 appears difficult, decreasing the risk of transmission is important. Treatment with 0.1 and 0.05 ppm ozone gas for 10 and 20 hr, respectively, decreased SARS-CoV-2 infectivity by about 95%. The magnitude of the effect was dependent on humidity. Treatment with 1 and 2 mg/L ozone water for 10 s reduced SARS-CoV-2 infectivity by about 2 and 3 logs, respectively. Our results suggest that low-dose ozone, in the form of gas and water, is effective against SARS-CoV-2.
AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the global coronavirus disease 2019 (COVID-19) pandemic. Because complete elimination of SARS-CoV-2 appears difficult, decreasing the risk of transmission is important. Treatment with 0.1 and 0.05 ppm ozone gas for 10 and 20 hr, respectively, decreased SARS-CoV-2 infectivity by about 95%. The magnitude of the effect was dependent on humidity. Treatment with 1 and 2 mg/L ozone water for 10 s reduced SARS-CoV-2 infectivity by about 2 and 3 logs, respectively. Our results suggest that low-dose ozone, in the form of gas and water, is effective against SARS-CoV-2.
KW - SARS-CoV-2
KW - TCID
KW - humidity
KW - ozone gas
KW - ozone water
UR - http://www.scopus.com/inward/record.url?scp=85097489248&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85097489248&partnerID=8YFLogxK
U2 - 10.1111/1348-0421.12861
DO - 10.1111/1348-0421.12861
M3 - Article
C2 - 33230863
AN - SCOPUS:85097489248
SN - 0385-5600
VL - 65
SP - 10
EP - 16
JO - MICROBIOLOGY and IMMUNOLOGY
JF - MICROBIOLOGY and IMMUNOLOGY
IS - 1
ER -