Regional accumulation of amyloid β A4 protein precursor in the gerbil brain following transient cerebral ischemia

Hideaki Wakita; Hidekazu Tomimoto; Ichiro Akiguchi; Katsunori Ohnishi; Shinichi Nakamura; Jun Kimura

doi:10.1016/0304-3940(92)90061-B

Regional accumulation of amyloid β A4 protein precursor in the gerbil brain following transient cerebral ischemia

Hideaki Wakita, Hidekazu Tomimoto, Ichiro Akiguchi, Katsunori Ohnishi, Shinichi Nakamura, Jun Kimura

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

59 被引用数 (Scopus)

抄録

Alterations of β A4 amyloid protein precursor (APP) were investigated immunohistochemically in the gerbil brain after transient global ischemia and subsequent reperfusion. Marked accumulation of this protein peaking at 24 h occurred in the neurons of the CA3 and paramedian region of the hippocampus as well as layers III, V and VI of the cerebral cortex. On the contrary, the accumulation was not observed in the neurons of the CA1 region. These results indicate that distribution of APP is altered depending on tissue viabilities after cerebral ischemia.

本文言語	英語
ページ（範囲）	135-138
ページ数	4
ジャーナル	Neuroscience Letters
巻	146
号	2
DOI	https://doi.org/10.1016/0304-3940(92)90061-B
出版ステータス	出版済み - 09-11-1992
外部発表	はい

All Science Journal Classification (ASJC) codes

神経科学一般

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10.1016/0304-3940(92)90061-B

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title = "Regional accumulation of amyloid β A4 protein precursor in the gerbil brain following transient cerebral ischemia",

abstract = "Alterations of β A4 amyloid protein precursor (APP) were investigated immunohistochemically in the gerbil brain after transient global ischemia and subsequent reperfusion. Marked accumulation of this protein peaking at 24 h occurred in the neurons of the CA3 and paramedian region of the hippocampus as well as layers III, V and VI of the cerebral cortex. On the contrary, the accumulation was not observed in the neurons of the CA1 region. These results indicate that distribution of APP is altered depending on tissue viabilities after cerebral ischemia.",

author = "Hideaki Wakita and Hidekazu Tomimoto and Ichiro Akiguchi and Katsunori Ohnishi and Shinichi Nakamura and Jun Kimura",

year = "1992",

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T1 - Regional accumulation of amyloid β A4 protein precursor in the gerbil brain following transient cerebral ischemia

AU - Wakita, Hideaki

AU - Tomimoto, Hidekazu

AU - Akiguchi, Ichiro

AU - Ohnishi, Katsunori

AU - Nakamura, Shinichi

AU - Kimura, Jun

PY - 1992/11/9

Y1 - 1992/11/9

N2 - Alterations of β A4 amyloid protein precursor (APP) were investigated immunohistochemically in the gerbil brain after transient global ischemia and subsequent reperfusion. Marked accumulation of this protein peaking at 24 h occurred in the neurons of the CA3 and paramedian region of the hippocampus as well as layers III, V and VI of the cerebral cortex. On the contrary, the accumulation was not observed in the neurons of the CA1 region. These results indicate that distribution of APP is altered depending on tissue viabilities after cerebral ischemia.

AB - Alterations of β A4 amyloid protein precursor (APP) were investigated immunohistochemically in the gerbil brain after transient global ischemia and subsequent reperfusion. Marked accumulation of this protein peaking at 24 h occurred in the neurons of the CA3 and paramedian region of the hippocampus as well as layers III, V and VI of the cerebral cortex. On the contrary, the accumulation was not observed in the neurons of the CA1 region. These results indicate that distribution of APP is altered depending on tissue viabilities after cerebral ischemia.

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JO - Neuroscience Letters

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Regional accumulation of amyloid β A4 protein precursor in the gerbil brain following transient cerebral ischemia

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