Regional accumulation of amyloid β A4 protein precursor in the gerbil brain following transient cerebral ischemia

Hideaki Wakita, Hidekazu Tomimoto, Ichiro Akiguchi, Katsunori Ohnishi, Shinichi Nakamura, Jun Kimura

研究成果: Article査読

56 被引用数 (Scopus)

抄録

Alterations of β A4 amyloid protein precursor (APP) were investigated immunohistochemically in the gerbil brain after transient global ischemia and subsequent reperfusion. Marked accumulation of this protein peaking at 24 h occurred in the neurons of the CA3 and paramedian region of the hippocampus as well as layers III, V and VI of the cerebral cortex. On the contrary, the accumulation was not observed in the neurons of the CA1 region. These results indicate that distribution of APP is altered depending on tissue viabilities after cerebral ischemia.

本文言語English
ページ(範囲)135-138
ページ数4
ジャーナルNeuroscience Letters
146
2
DOI
出版ステータスPublished - 09-11-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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