Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57Black/6 and SV129 mice

K. Maeda, Ryuji Hata, K. A. Hossmann

研究成果: Article

52 引用 (Scopus)

抄録

C57Black/6 and SV129 mice are widely used for the production of transgenic mutants in molecular stroke research but the ischemic susceptibility of these strains is influenced by differences in vascular anatomy and the responsiveness to excitotoxins and vasodilatory stimuli. To differentiate between these opposing effects on infarct size, the vascular territory of the two strains was correlated with the hemodynamic, metabolic, and morphological consequences of permanent middle cerebral artery (MCA) occlusion. The vascular anatomy was studied by latex infusion, brain infarction by vital staining, the size of the ischemic penumbra by imaging of ATP and protein synthesis, and blood flow by laser-Doppler flowmetry. In C57Black/6 mice the MCA-supplied vascular territory and the size of brain infarcts were significantly larger than in SV129 mice but the size of the penumbra and the residual blood flow in the center of the MCA-supplying territory were similar in both strains. These findings suggest that differences in infarct size in C57Black/6 and SV129 mice are determined mainly by the vascular anatomy and not by differences in collateral vascular responsiveness or excitotoxicity.

元の言語English
ページ(範囲)101-108
ページ数8
ジャーナルNeurobiology of Disease
6
発行部数2
DOI
出版物ステータスPublished - 01-01-1999

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Middle Cerebral Artery Infarction
Blood Vessels
Anatomy
Middle Cerebral Artery
Brain Infarction
Laser-Doppler Flowmetry
Latex
Neurotoxins
Blood Proteins
Adenosine Triphosphate
Hemodynamics
Stroke
Staining and Labeling
Brain
Research

All Science Journal Classification (ASJC) codes

  • Neurology

これを引用

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