TY - JOUR
T1 - Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate
AU - Kizuka, Yasuhiko
AU - Oka, Shogo
PY - 2012/12
Y1 - 2012/12
N2 - Human natural killer-1 (HNK-1) carbohydrate, comprising a unique trisaccharide HSO3-3GlcAb1-3Galb1- 4GlcNAc, shows well-regulated expression and unique functions in the nervous system. Recent studies have revealed sophisticated and complicated expression mechanisms for HNK-1 glycan. Activities of biosynthetic enzymes are controlled through the formation of enzymecomplexes and regulation of subcellular localization. Functional aspects of HNK-1 carbohydrate were examined by overexpression, knockdown, and knockout studies of these enzymes. HNK-1 is involved in several neural functions such as synaptic plasticity, learning and memory, and the underlying molecular mechanisms have been illustrated upon identification of the target carrier glycoproteins of HNK-1 such as the glutamate receptor subunit GluA2 or tenascin-R. In this review, we describe recent findings about HNK-1 carbohydrate that provide further insights into the mechanism of its expression and function in the nervous system.
AB - Human natural killer-1 (HNK-1) carbohydrate, comprising a unique trisaccharide HSO3-3GlcAb1-3Galb1- 4GlcNAc, shows well-regulated expression and unique functions in the nervous system. Recent studies have revealed sophisticated and complicated expression mechanisms for HNK-1 glycan. Activities of biosynthetic enzymes are controlled through the formation of enzymecomplexes and regulation of subcellular localization. Functional aspects of HNK-1 carbohydrate were examined by overexpression, knockdown, and knockout studies of these enzymes. HNK-1 is involved in several neural functions such as synaptic plasticity, learning and memory, and the underlying molecular mechanisms have been illustrated upon identification of the target carrier glycoproteins of HNK-1 such as the glutamate receptor subunit GluA2 or tenascin-R. In this review, we describe recent findings about HNK-1 carbohydrate that provide further insights into the mechanism of its expression and function in the nervous system.
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U2 - 10.1007/s00018-012-1036-z
DO - 10.1007/s00018-012-1036-z
M3 - Review article
C2 - 22669261
AN - SCOPUS:84870658051
SN - 1420-682X
VL - 69
SP - 4135
EP - 4147
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 24
ER -