Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate

Yasuhiko Kizuka, Shogo Oka

研究成果: ジャーナルへの寄稿総説査読

47 被引用数 (Scopus)

抄録

Human natural killer-1 (HNK-1) carbohydrate, comprising a unique trisaccharide HSO3-3GlcAb1-3Galb1- 4GlcNAc, shows well-regulated expression and unique functions in the nervous system. Recent studies have revealed sophisticated and complicated expression mechanisms for HNK-1 glycan. Activities of biosynthetic enzymes are controlled through the formation of enzymecomplexes and regulation of subcellular localization. Functional aspects of HNK-1 carbohydrate were examined by overexpression, knockdown, and knockout studies of these enzymes. HNK-1 is involved in several neural functions such as synaptic plasticity, learning and memory, and the underlying molecular mechanisms have been illustrated upon identification of the target carrier glycoproteins of HNK-1 such as the glutamate receptor subunit GluA2 or tenascin-R. In this review, we describe recent findings about HNK-1 carbohydrate that provide further insights into the mechanism of its expression and function in the nervous system.

本文言語英語
ページ(範囲)4135-4147
ページ数13
ジャーナルCellular and Molecular Life Sciences
69
24
DOI
出版ステータス出版済み - 12-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 分子生物学
  • 薬理学
  • 細胞および分子神経科学
  • 細胞生物学

フィンガープリント

「Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル